Table 1 Characteristics of patients at baseline
Variable | Visceral to subcutaneous adipose tissue ratio (VAT/SAT) | ||
|---|---|---|---|
< median (n = 36) | ≥ median (n = 37) | p value | |
Baseline characteristics | |||
 Age, (IQR) | 38–70 | 56–68 | 0.025 |
 Male, n (%) | 18 (50.0) | 35 (94.6) | <0.001 |
 Caucasians, n (%) | 31 (93.9)a | 20 (80.0) | 0.145 |
Chronic condition, n (%) | |||
 Hypertension | 14 (38.9) | 12 (32.4) | 0.740 |
 Congestive heart failure | 4 (11.1) | 3 (8.1) | 0.711 |
 Myocardial infarction | 3 (8.3) | 3 (8.1) | 0.136 |
 Diabetes mellitus | 9 (25.0) | 10 (27.0) | 1.000 |
 COPD | 5 (13.9) | 11 (29.7) | 0.176 |
 Chronic kidney disease | 2 (5.6) | 6 (16.2) | 0.261 |
 Cirrhosis | 1 (2.8) | 4 (10.8) | 0.358 |
 Malignancy | 2 (5.6) | 2 (5.4) | 1.000 |
Hemodynamic variables at admission (IQR) | |||
 Mean arterial pressure | 66–89 | 72–84 | 0.911 |
 Heart rate | 83–104 | 79–115 | 0.704 |
 Respiratory rateb | 16–20 | 17–22 | 0.323 |
 Temperature (°C) | 36.4–37.2 | 36.3–37.1 | 0.661 |
Laboratory measurements at admission (IQR) | |||
 Hemoglobin (g/L) | 88.0–130.0 | 87.0–127.0 | 0.467 |
 WBC (×103/mm3) | 5.90–12.97 | 6.67–17.65 | 0.220 |
 Platelets (109/L) | 128–362 | 119–230 | 0.075 |
 Creatinine (mmol/L) | 64–119 | 77–180 | 0.039 |
 Lactate (mmol/L) | 1.1–1.9 | 1.3–3.3 | 0.179 |
Other clinical characteristics | |||
 APACHE II score (IQR) | 3–12 | 8–17 | 0.028 |
 Use of vasopressor, n (%) | 6 (16.7) | 6 (16.2) | 0.871 |
 Mechanical ventilation, n (%) | 12 (33.3) | 14 (37.8) | 0.444 |
PCSK9 genotype, n (%) | |||
 One or more loss-of-function | 20 (55.6) | 15 (40.5) | 0.294 |
 Two or more loss-of-function | 5 (13.9) | 9 (24.3) | 0.404 |
 Adipose tissue area (cm2) (IQR) | |||
 Visceral adipose tissue | 44.7–138.5 | 126.8–279.5 | <0.001 |
 Subcutaneous adipose tissue | 116.5–270.8 | 99.8–212.2 | 0.300 |