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Fig. 4 | Critical Care

Fig. 4

From: Survival benefit of a low ratio of visceral to subcutaneous adipose tissue depends on LDL clearance versus production in sepsis

Fig. 4

a Patients who have the wild type genotype (n = 34) with low visceral adipose tissue/subcutaneous adipose tissue (VAT/SAT) (n = 15) have higher low-density lipoprotein (LDL) (median and interquartile range, mg/dL) than patients with high VAT/SAT (n = 19) (p = 0.000082). b Patients who have PCSK9 loss-of-function genotype (n = 35) have low LDL levels regardless of VAT/SAT category (p value not significant). c In patients who have wild type genotype (n = 34) there is no significant difference in survival between those with low VAT/SAT (n = 15) or high VAT/SAT (n = 19) (p value not significant). d Patients who have PCSK9 loss-of-function genotype (n = 35) with low VAT/SAT (n = 20) have longer survival compared to patients with high VAT/SAT (n = 15) (p = 0.017). Four patients who carried PCSK9 gain-of-function mutations were excluded from this analysis (n = 69)

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Critical Care

ISSN: 1364-8535