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nAChR
|
|
Muscle-type
|
Neuromuscular junction
|
Muscle contraction, mainly by increased Na+ and K+ permeability
|
|
Neuronal-type
|
Autonomic ganglia
|
Activation of autonomic nervous system (sympathetic and parasympathetic), mainly by increased Na+and K+ permeability
|
|
Hippocampus / cortex
|
Cognition, modulate the induction of synaptic plasticity, effect on learning and memory formation, i.e., can improve neurovascular coupling
|
|
Midbrain
|
Reward center and initiation of the nicotine addiction process
|
|
Neuro-endocrineneurons in the hypothalamus
|
Facilitate the Ca2+-dependent release of vasopressin and oxytocin
|
|
Others
|
Improvement of neurovascular coupling (in neurodegenerative disease and ischemia)
|
|
mAChR
|
|
M1
|
Autonomic ganglia
|
Mediates slow EPSP in postganglionic nerve
|
|
Exocrine glands
|
Stimulates secretion
|
|
Central nervous system
|
Activates slow after-depolarizing potentials in neurons
|
|
M2
|
Heart
|
Reduce of heart rate, contractile forces of the atrium and conduction velocity in AV node
|
|
Central nervous system
|
Activates slow after-depolarizing potentials in neurons
|
|
M3
|
Smooth muscles
|
Vasoconstriction, vasodilatation, bronchoconstriction
|
|
Endocrine and exocrine glands
|
Stimulate secretion
|
|
Central nervous system
|
Activates slow after-depolarizing potentials in neurons
|
|
Eye
|
Lacrimation, miosis and accommodation by contraction of the sphincter papillae and ciliary body
|
|
M4
|
Central nervous system
|
Activates slow after-depolarizing potentials in neurons
|
|
M5
|
Not well known
|
-
|
