nAChR
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Muscle-type
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Neuromuscular junction
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Muscle contraction, mainly by increased Na+ and K+ permeability
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Neuronal-type
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Autonomic ganglia
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Activation of autonomic nervous system (sympathetic and parasympathetic), mainly by increased Na+and K+ permeability
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Hippocampus / cortex
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Cognition, modulate the induction of synaptic plasticity, effect on learning and memory formation, i.e., can improve neurovascular coupling
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Midbrain
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Reward center and initiation of the nicotine addiction process
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Neuro-endocrineneurons in the hypothalamus
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Facilitate the Ca2+-dependent release of vasopressin and oxytocin
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Others
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Improvement of neurovascular coupling (in neurodegenerative disease and ischemia)
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mAChR
|
M1
|
Autonomic ganglia
|
Mediates slow EPSP in postganglionic nerve
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Exocrine glands
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Stimulates secretion
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Central nervous system
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Activates slow after-depolarizing potentials in neurons
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M2
|
Heart
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Reduce of heart rate, contractile forces of the atrium and conduction velocity in AV node
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Central nervous system
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Activates slow after-depolarizing potentials in neurons
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M3
|
Smooth muscles
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Vasoconstriction, vasodilatation, bronchoconstriction
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Endocrine and exocrine glands
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Stimulate secretion
|
Central nervous system
|
Activates slow after-depolarizing potentials in neurons
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Eye
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Lacrimation, miosis and accommodation by contraction of the sphincter papillae and ciliary body
|
M4
|
Central nervous system
|
Activates slow after-depolarizing potentials in neurons
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M5
|
Not well known
|
-
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