Table 4 Association of tight glucose control vs usual care with outcomes among critically ill adults, stratified by with cardiac surgery or without cardiac surgery
From: Tight glycemic control in critically ill pediatric patients: a systematic review and meta-analysis
Subgroup of trials | Number of trials | Event number/total number (%) | OR (95% CI) | I2 (%) | |
|---|---|---|---|---|---|
Tight control | Usual control | ||||
Mortality | |||||
Noncardiac surgery | 3 | 57/441 (12.9) | 45/394 (9.2) | 1.29 (0.52–3.23) | 29 |
Cardiac surgery | 3 | 53/1533 (3.5) | 64/1516 (4.2) | 0.79 (0.50–1.26) | 26 |
Overall | 6 | 110/1974 (5.6) | 113/2047 (5.0) | 0.95 (0.62–1.45) | 40 |
Any hypoglycemia (< 60 mg/dl) | |||||
Noncardiac surgery | 2 | 104/342 (30.4) | 45/394 (11.4) | 2.97 (2.01–4.41) | 0 |
Cardiac surgery | 3 | 267/1533 (17.4) | 71/1516 (4.7) | 5.72 (1.95–16.73) | 91 |
Overall | 5 | 371/1925 (19.3) | 116/1910 (6.1) | 4.39 (2.39–8.06) | 83 |
Severe hypoglycemia (< 40 mg/dl) | |||||
Noncardiac surgery | 2 | 25/392 (6.4) | 9/394 (2.3) | 2.95 (1.35–6.42) | 0 |
Cardiac surgery | 3 | 84/1533 (5.5) | 18/1516 (1.2) | 4.76 (2.84–7.97) | 91 |
Overall | 5 | 109/1925 (18.4) | 27/1910 (5.8) | 4.11 (2.67–6.32) | 0 |
Sepsis | |||||
Noncardiac surgery | 3 | 52/441 (11.8) | 79/531 (14.9) | 0.82 (0.55–1.22) | 67 |
Cardiac surgery | 3 | 164/1633 (10.0) | 196/1516 (19.2) | 0.79 (0.62–1.00) | 0 |
Overall | 6 | 216/1947 (11.0) | 275/2047 (13.4) | 0.83 (0.63–1.08) | 32 |
Dialysis | |||||
Noncardiac surgery | 3 | 69/1533 (4.5) | 103/1516 (6.8) | 0.63 (0.45–0.86) | 0 |
Cardiac surgery | 0 | NA | NA | NA | NA |
Overall | 3 | 69/1533 (4.5) | 103/1516 (6.8) | 0.63 (0.45–0.86) | 0 |
Seizures | |||||
Noncardiac surgery | 1 | 5/349 (1.4) | 10/349 (2.9) | 0.49 (0.17–1.46) | NA |
Cardiac surgery | 2 | 26/1533 (1.7) | 21/1165 (1.8) | 1.22 (0.68–2.18) | 50 |
Overall | 3 | 31/1533 (2.0) | 31/1514 (2.0) | 0.98 (0.59–1.63) | 51 |