Table 3 Association of tight glucose control vs usual care with outcomes among critically ill adults, stratified by tight control glucose goal
From: Tight glycemic control in critically ill pediatric patients: a systematic review and meta-analysis
Subgroup of trialsa | Number of trials | Event number/total number (%) | OR (95% CI) | I2 (%) | |
|---|---|---|---|---|---|
Tight control | Usual control | ||||
Mortality | |||||
Very tight control | 2 | 12/392 (3.1) | 19/369 (5.1) | 1.11 (0.12–10.60) | 73 |
Moderately tight control | 4 | 98/1582 (6.2) | 94/1651 (5.7) | 1.10 (0.81–1.49) | 0 |
Overall | 6 | 110/1974 (2.9) | 113/2047 (5.5) | 0.95 (0.62–1.45) | 40 |
Any hypoglycemia (< 60 mg/dl) | |||||
Very tight control | 2 | 112/392 (28.6) | 17/396 (4.3) | 9.35 (1.49–58.83) | 88 |
Moderately tight control | 3 | 259/1533 (16.9) | 99/1514 (6.5) | 3.00 (2.07–4.34) | 54 |
Overall | 5 | 371/1925 (19.3) | 116/1910 (6.1) | 4.39 (2.39–8.06) | 83 |
Severe hypoglycemia (< 40 mg/dl) | |||||
Very tight control | 2 | 24/392 (6.1) | 5/396 (8.7) | 5.23 (1.95–14.00) | 0 |
Moderately tight control | 3 | 85/1533 (5.5) | 22/1514 (1.5) | 3.88 (2.41–6.26) | 0 |
Overall | 5 | 109/1925 (18.4) | 27/1910 (5.8) | 4.11 (2.67–6.32) | 0 |
Sepsis | |||||
Very tight control | 2 | 121/392 (30.9) | 143/396 (36.1) | 1.01 (0.43–2.41) | 73 |
Moderately tight control | 4 | 95/1582 (6.0) | 132/1651 (8.0) | 0.81 (0.59–1.12) | 18 |
Overall | 6 | 216/1947 (11.1) | 275/2047 (13.4) | 0.83 (0.63–1.08) | 32 |
Dialysis | |||||
Very tight control | 1 | 2/349 (0.6) | 6/351 (1.7) | 0.33 (0.07–1.65) | NA |
Moderately tight control | 2 | 67/1184 (5.7) | 97/1165 (8.3) | 0.64 (0.46–0.89) | 0 |
Overall | 3 | 69/1533 (4.5) | 103/1516 (6.8) | 0.63 (0.45–0.86) | 0 |
Seizures | |||||
Very tight control | 0 | NA | NA | NA | NA |
Moderately tight control | 3 | 31/1533 (2.0) | 31/1514 (2.0) | 0.98 (0.59–1.63) | 51 |
Overall | 3 | 31/1533 (2.0) | 31/1514 (2.0) | 0.98 (0.59–1.63) | 51 |