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Table 2 Baseline demographics of four groups of patients specified in our multivariable regression model

From: Neuromuscular blockade is associated with the attenuation of biomarkers of epithelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome

Characteristic Low P/F and LTVV High P/F and LTVV Low P/F and HTVV High P/F and HTVV Overall p value
n 107 115 113 111
Age, years 51.4 ± 14.3 48.8 ± 16.1 51.0 ± 16.8 51.4 ± 16.9 0.56
Female 50 (47%) 41 (36%) 51 (45%) 42 (38%) 0.26
APACHE III 88.3 ± 29.5 76.8 ± 28.0 87.3 ± 28.2 80.9 ± 26.6 0.006
Initial P/F ratio 84.5 ± 20.8 183.9 ± 46.5 84.0 ± 19.9 175.3 ± 47.5 < 0.001
Initial driving pressure 14.9 ± 5.3 22.9 ± 7.0 16.9 ± 5.4 24.6 ± 6.6 < 0.001
Mean PaO2 (mmHg) 74.1 ± 18.2 83.5 ± 21.3 75.4 ± 11.7 83.0 ± 15.7 < 0.001
Mean FiO2 (%) 62.1 ± 15.3 49.0 ± 12.2 58.2 ± 14.0 47.6 ± 11.8 < 0.001
Mean PEEP (cm H20) 9.9 ± 2.8 7.7 ± 2.6 9.1 ± 3.2 7.2 ± 2.3 < 0.001
Lowest systolic blood pressure 87.6 ± 19.4 92.3 ± 19.3 87.7 ± 18.1 92.3 ± 17.4 0.07
Highest temperature 38.6 ± 0.9 38.5 ± 0.8 38.5 ± 1.1 38.4 ± 0.83 0.33
Mean pH 7.32 ± 0.53 7.24 ± 0.90 7.29 ± 0.79 7.30 ± 0.70 0.88
Platelet count 161.0 ± 115.1 149.7 ± 115.5 162.8 ± 94.5 144.1 ± 100.7 0.51
Pneumonia 49 (45.8%) 29 (25.2%) 53 (46.9%) 39 (35.1%) 0.002
Sepsis 28 (26.1%) 36 (31.3%) 23 (20.3%) 27 (24.3%) 0.29
Aspiration 15 (14.0%) 17 (14.8%) 17 (15.0%) 14 (12.6%) 0.95
Multiple transfusions 4 (3.7%) 1 (0.8%) 3 (2.7%) 9 (8.1%) 0.03
Trauma 3 (2.8%) 23 (20.0%) 4 (3.5%) 14 (12.6%) < 0.001
Other 7 (6.5%) 9 (7.8%) 13 (8.8%) 8 (7.2%) 0.54
Days of NMB, median (25–75 IQR) 0 (0–1) 0 (0–0) 0 (0–1) 0 (0–1) 0.62a
  1. Values are shown as either mean ± SD or n (%), unless otherwise indicated
  2. P value < 0.003 significant after Bonferroni correction for multiple comparisons
  3. APACHE Acute Physiology and Chronic Health Evaluation, FiO 2 fractional inspired oxygen, LTVV low tidal volume ventilation, IQR interquartile range, LTVV low tidal volume ventilation, NMB neuromuscular blockade, PEEP positive end-expiratory pressure, PaO 2 arterial oxygen tension, P/F PaO2/FiO2
  4. aTested by Wilcoxon Rank Sum