From: Vasoplegia treatments: the past, the present, and the future
Receptor type | Adrenoceptor α | Adrenoceptor β | Vasopressin receptor | Angiotensin receptor | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 | α1 | α2 | β1 | β2 | β3 | V1a | V1b | V2 | AT-R1 | AT-R2 |
Drug affinity | Ep = NEp | Ep > NEp | Ep < NEp | Ep > NEp | Ep = NEp | Vasopressin | Vasopressin | Vasopressin | Angiotensin II | |
Selipressin | Desmopressin | |||||||||
Terlipressin | Terlipressin | |||||||||
Vascular agonistic effects | Vasoconstriction | Vasorelaxation | Vasorelaxation | Vasorelaxation | Unknown | Vasoconstriction | NA | Vasorelaxation | Vasoconstriction | Vasorelaxation |
Inflammation effect | Down-regulation ++ | Down-regulation ++ | Down-regulation + | Down-regulation + | Unknown | Down-regulation | Down-regulation | Down-regulation | Unknown | Unknown |
Second messengers | PLC-DAG-IP3-PKC | AC-cAMP-PKA (−) | AC-cAMP-PKA (+) |  | Unknown | PLC-DAG-IP3-PKC | PLC-DAG-IP3-PKC | AC-cAMP | PLC-DAG-IP3-PKC | Unknown |
Main localization | Post-synaptic receptors | Extrajunctional post-synaptic receptors | Post-synaptic receptors | Extrajunctional post-synaptic receptors | Unknown | Vascular smooth muscle cells | Anterior pituitary gland | Vascular smooth muscle cells | Medullary interstitial cells +++ | Adrenal gland |
 | Vascular smooth muscle cells α1>>α2 | Vascular smooth muscle cells β2>>β1 | Hepatocytes | Basolateral membrane of collecting duct | Brain | Brain | ||||
 | Coronary circulation (large artery) | Coronary circulation (large and small arteries) β1>>β2 | Myometrium | Vascular endothelium | Myocytes | Myocytes | ||||
 | Cerebral circulation (not smaller vessels) | Cerebral circulation | Platelets | Vascular smooth muscle cells | ||||||
 | Skeletal and pulmonary (α>>β) | Skeletal and pulmonary | Renal glomeruli and proximal tubules | |||||||
 |  | Splanchnic | Splanchnic (β2>>β1) |