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Table 1 Characteristics of studies that have used animal models relevant to the critically ill patient population

From: Renal autoregulation and blood pressure management in circulatory shock

Study Species Model Interventions Key findings
Adams et al. 1980 [46] Dog Ischemia/reperfusion (clamp time 90 min) - Diminished autoregulatory efficiency at 18 h
Matthys et al. 1983 [47] Rat Ischemia/reperfusion (clamp time 45 min) - Loss of autoregulation at 48 h and 7 days after clamping
Williams et al. 1981 [48] Dog Ischemia/reperfusion (clamp time 60–90 min) - Attenuated autoregulatory reserve at 18 to 24 h after clamping. Strong negative correlation autoregulatory index and inulin clearance
Verbeke et al. 1998 [49] Rat Ischemia/reperfusion (clamp time 40 min) Ketanserin Renal autoregulation lost at 2 and 24 h after clamping. Ketanserin partially restored autoregulation at 24 but not at 2 h
Conger et al. 1991 [50] Rat Ischemia/reperfusion by clamping or NE-infusion (clamp time 75 min; NE at 0.6 μg/kg/min for 90 min) - Impaired autoregulatory efficiency at 1 week, worse with NE vs clamping
Conger et al. 1994 [51] Rat 4-h MAP reduction by phlebotomy, 1 week after ischemia/reperfusion by clamping or NE-infusion (clamp time 75 min; NE at 0.6 μg/kg/min for 90 min) - Impaired autoregulatory efficiency, worse with clamping vs NE, associated with functional and structural deficits
Guan et al. 2006 [52] Rat Ischemia/reperfusion by unilateral or bilateral clamping for 30 or 60 min -  
Rhee et al. 2012 [32] Piglet Hemorrhagic shock; stepwise MAP reductions from 80 to 60, 45, and 40 mmHg - Early passive pressure–flow relationship between blood pressure and RBF suggests loss of renal before cerebral autoregulation
Burban et al. 2013 [57] Rat Cecal ligation and puncture. Reconstruction of autoregulatory curve using MAP reductions by acute bleeding - Renal autoregulation unaffected by sepsis, with or without NE
Nitescu et al. 2010 [58] Rat Endotoxemia by LPS bolus infusion. Dynamic analysis of renal autoregulation Candesartan Reduced transfer gain values in TGF-associated frequency range after 16 h, which normalized with angiotensin II receptor antagonism
  1. NE norepinephrine, LPS lipopolysaccharide, MAP mean arterial pressure, TGF tubuloglomerular feedback, RBF renal blood flow