Table 1 Characteristics of studies that have used animal models relevant to the critically ill patient population
From: Renal autoregulation and blood pressure management in circulatory shock
Study | Species | Model | Interventions | Key findings |
|---|---|---|---|---|
Adams et al. 1980 [46] | Dog | Ischemia/reperfusion (clamp time 90 min) | - | Diminished autoregulatory efficiency at 18 h |
Matthys et al. 1983 [47] | Rat | Ischemia/reperfusion (clamp time 45 min) | - | Loss of autoregulation at 48 h and 7 days after clamping |
Williams et al. 1981 [48] | Dog | Ischemia/reperfusion (clamp time 60–90 min) | - | Attenuated autoregulatory reserve at 18 to 24 h after clamping. Strong negative correlation autoregulatory index and inulin clearance |
Verbeke et al. 1998 [49] | Rat | Ischemia/reperfusion (clamp time 40 min) | Ketanserin | Renal autoregulation lost at 2 and 24 h after clamping. Ketanserin partially restored autoregulation at 24 but not at 2 h |
Conger et al. 1991 [50] | Rat | Ischemia/reperfusion by clamping or NE-infusion (clamp time 75 min; NE at 0.6 μg/kg/min for 90 min) | - | Impaired autoregulatory efficiency at 1 week, worse with NE vs clamping |
Conger et al. 1994 [51] | Rat | 4-h MAP reduction by phlebotomy, 1 week after ischemia/reperfusion by clamping or NE-infusion (clamp time 75 min; NE at 0.6 μg/kg/min for 90 min) | - | Impaired autoregulatory efficiency, worse with clamping vs NE, associated with functional and structural deficits |
Guan et al. 2006 [52] | Rat | Ischemia/reperfusion by unilateral or bilateral clamping for 30 or 60 min | - | Â |
Rhee et al. 2012 [32] | Piglet | Hemorrhagic shock; stepwise MAP reductions from 80 to 60, 45, and 40 mmHg | - | Early passive pressure–flow relationship between blood pressure and RBF suggests loss of renal before cerebral autoregulation |
Burban et al. 2013 [57] | Rat | Cecal ligation and puncture. Reconstruction of autoregulatory curve using MAP reductions by acute bleeding | - | Renal autoregulation unaffected by sepsis, with or without NE |
Nitescu et al. 2010 [58] | Rat | Endotoxemia by LPS bolus infusion. Dynamic analysis of renal autoregulation | Candesartan | Reduced transfer gain values in TGF-associated frequency range after 16 h, which normalized with angiotensin II receptor antagonism |