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Table 3 Area under the curve (AUC) and thresholds for predicting total mortality in patients with SCAP

From: Serum suPAR and syndecan-4 levels predict severity of community-acquired pneumonia: a prospective, multi-centre study

 ThresholdSensitivity (%)Specificity (%)AUCp value95% CI
Lower limitHigher limit
suPAR (ng/mL)≥10.2268.23%89.29%0.772<0.0010.6360.908
Syndecan-4 (ng/mL)≤6.6873.68%71.43%0.744<0.0010.6180.870
WBC (×109/L)>16.4036.84%83.33%0.5580.4890.3930.723
CRP (mg/L)>164.1542.86%73.97%0.5330.7010.3630.703
PCT (μg/L)>0.3485.71%41.56%0.6180.1370.4620.774
APACHE II>1484.21%60.71%0.743<0.0010.6360.851
  1. SCAP severe community-acquired pneumonia, suPAR soluble urokinase-type plasminogen activator receptor, WBC whole blood leukocyte count, NLR neutrophil/lymphocyte ratio, CRP C-reactive protein, PCT procalcitonin, CURB-65 confusion, urea, respiratory rate, blood pressure, and age ≥65 years old score, PSI Pneumonia Severity Index score, APACHE II Acute Physiology and Chronic Health Evaluation II score