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Table 2 Area under the curve (AUC) and thresholds for predicting SCAP in patients with CAP

From: Serum suPAR and syndecan-4 levels predict severity of community-acquired pneumonia: a prospective, multi-centre study

 ThresholdSensitivity (%)Specificity (%)AUCp value95% CI
Lower limitHigher limit
suPAR (ng/mL)>4.3376.70%79.19%0.835<0.0010.7830.878
Syndecan-4 (ng/mL)≤6.1033.01%81.88%0.5500.1870.4870.613
WBC (×109/L)>12.1541.75%79.19%0.6280.0010.5650.687
NLR>5.6176.24%61.02%0.725<0.0010.6610.783
CRP (mg/L)>90.4856.32%73.27%0.6420.0010.5690.710
PCT (μg/L)>0.4853.85%75.44%0.701<0.0010.6200.773
CURB-65>070.87%68.35%0.742<0.0010.6820.796
PSI>8756.86%92.03%0.787<0.0010.7290.837
APACHE II>1078.64%82.55%0.886<0.0010.8400.923
  1. SCAP severe community-acquired pneumonia, CAP community-acquired pneumonia, suPAR soluble urokinase-type plasminogen activator receptor, WBC whole blood leukocyte count, NLR neutrophil/lymphocyte ratio, CRP C-reactive protein, PCT procalcitonin, CURB-65 confusion, urea, respiratory rate, blood pressure, and age ≥65 years old score, PSI Pneumonia Severity Index score, APACHE II Acute Physiology and Chronic Health Evaluation II score