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Table 4 Fractional target attainment (FTA) for empiric therapy for P. aeruginosa strains at and below the resistance breakpoint (MIC ≤ 8 mg/L, 52,771 isolates)

From: Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study

RD
[mL/d]
Dose (40% f T > MIC) Dose (100% f T > MIC)
0.5 g
q12
0.5 g
q8
1 g
q12
1 g
q8
2 g
q8
2 g
Q8 PI
0.5 g
q12
0.5 g
q8
1 g
q12
1 g
q8
2 g
q8
2 g
Q8 PI
0 94.8 98.1 99.1 99.8 99.9 100 87.9 91.2 95.3 97.5 99.6 97.7
100 92.4 96.1 98.2 99.6 99.9 99.9 79.5 86.7 88.8 93.9 98.8 95.9
300 86.9 91.7 94.2 97.7 99.9 99.9 58.8 75.3 71.9 75.5 92.2 94.3
  1. RD residual diuresis, f T > MIC percentage of time remaining concentration above MIC, PI prolonged infusion (3 h)