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Table 3 Fractional target attainment (FTA) for directed therapy for susceptible P. aeruginosa (MIC < 2 mg/L, 45,715 isolates)

From: Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study

RD
[mL/d]
Dose (40% f T > MIC) Dose (100% f T > MIC)
0.5 g
q12
0.5 g
q8
1 g
q12
1 g
q8
2 g
q8
0.5 g
q12
0.5 g
q8
1 g
q12
1 g
q8
2 g
q8
0 99.9 99.9 100 100 100 94.0 99.3 99.7 99.9 100
100 99.7 99.9 99.9 100 100 91.3 97.5 97.5 99.6 99.9
300 97.8 99.6 99.7 99.9 100 67.8 86.3 81.8 86.6 97.0
  1. RD residual diuresis, f T > MIC percentage of time remaining concentration above MIC