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Table 2 Parameter estimates for meropenem from the final covariate two-compartment population pharmacokinetic model

From: Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study

Variable Mean Standard deviation Coefficient of variation (%) Median
CLSLED (L/h) 7.9 4.2 53.6 6.8
CLN (L/h) 1.5 2.1 134.7 0.7
CLD (L/h) 2.6 1.2 44.9 2.3
Vc (L) 8.1 7.1 87.9 4.9
KCP 10.3 8.8 85.4 7.9
KPC 1.8 1.9 104.4 1.2
  1. CLSLED clearance on SLED, CLN clearance native, CLD clearance related to other mechanisms, Vc volume of distribution of the central compartment, KCP constant for the distribution of meropenem from the central to the peripheral compartment, KPC constant for the distribution of meropenem from the peripheral to the central compartment