Table 1 Baseline characteristics
Variable | Usual care (n = 48) | Intervention (n = 51) |
|---|---|---|
Age, years, mean (SD) | 60 (17) | 59 (17) |
Sex, male, n (%) | 35 (73) | 35 (69) |
BMI, kg/m2, mean (SD) | 30 (6) | 29 (6) |
APACHE II score, mean (SD) | 19 (7) | 18 (7) |
APACHE III diagnosis code, n (%) | ||
 Cardiovascular | 29 (59) | 31 (61) |
 Trauma | 7 (14) | 6 (12) |
 Respiratory | 6 (12) | 3 (6) |
 Sepsis | 1 (2) | 7 (14) |
 Gastrointestinal | 1 (2) | 2 (4) |
 Musculoskeletal | 2 (4) | 0 (0) |
 Renal | 1 (2) | 1 (2) |
 Unknown | 1 (2) | 1 (2) |
 Neurological | 1 (2) | 0 (0) |
Location prior to ICU admission, n (%) | ||
 Elective surgery | 20 (42) | 22 (43) |
 ICU | 9 (19) | 7 (14) |
 Emergency surgery | 9 (19) | 5 (10) |
 ED | 5 (10) | 8 (16) |
 Ward | 4 (8) | 6 (12) |
 Other hospital | 1 (2) | 3 (6) |
Time from hospital admission to randomization, days, median [IQR] | 3 [3–6] | 3 [3–4] |
Time from ICU admission to randomization, days, mean (SD) | 2.5 (0.4) | 2.5 (0.4) |
Baseline total SOFA, mean (SD) | 10 (3) | 10 (4) |
Bloods, median [IQR] | ||
 ALT, U/L | 25 [11–103] | 40 [18–108] |
 ALP, U/L | 67 [49–97] | 72 [50–89] |
 GGT, U/L, mean (SD) | 44 [27–79] | 41 [28–98] |
 Bilirubin, mmol/L | 21 [10–41] | 24 [11–47] |
 WCC, 0^9/L | 13 [10–15] | 17 [11–23] |
 TG, mmol/L | 2 [1–3] | 2 [1–3] |
 CRP, mg/L | 209 (97) | 217 (111) |
Mid arm muscle circumference, cm, mean (SD) | 34 (5) | 34 (4) |