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Table 1 Characteristics of the included studies

From: Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis

Study/year Sample size (I/C) Setting Prophylaxis drugs Comparator Patient characteristics (I/C)
Age, mean, (years) Disease severity, median (IQR) or mean (SD) Patient receiving EN, n/N (%) MV (%) Follow up (months)
Alhazzani et al. 2017 [18] 49/42 Mixed Pantoprazole 40 mg once daily IV Placebo 62/55 APACHE II score
21 (17–26)/22(14–27)
81/91 (89) 100/100 Unknown
El-Kersh et al. 2017 [29] 55/47 MICU Pantoprazole 40 mg once daily IV Placebo 62/58 SAPS II score
41 (34.5–53)/44 (34–54)
102/102 (100) 100/100 Unknown
Selvanderan et al. 2016 [27] 106/108 Mixed Pantoprazole 40 mg once daily IV Placebo 52/52 APACHE III score
66 (26)/66 (28)
214/214 (100) 100/100 12
Lin et al. 2016 [28] 60/60 Mixed Lansoprazole OD 30 mg once daily No prophylaxis 67/65 APACHE II score
21.3 (6.7)/19.9 (6.9)
120/120 (100) 100/100 1
Ben-menachem et al. 1994 [22] 200/100 MICU Cimetidine 900 mg Infusion
Sucralfate OD 1 g every 6 h
No prophylaxis 60/60 APACHE II score
17.4 (7.3)/16.5 (6.9)
198/300 (67) 74/65 10
Apte et al. 1992 [21] 16/18 MICU Ranitidine 50 mg/every 6 h IV No prophylaxis 27/26 MTS score
11 (4–16)/10 (6–16)
34/34 (100) 31/22 Unknown
Van den Berg et al. 1985 [23] 14/14 Mixed Cimetidine 20 mg/kg/every 24 h IV Placebo 44/48 - 17/28 (61) 100/100 Unknown
  1. APACHE II acute physiology and chronic health evaluation II, EN enteral nutrition, IQR interquartile range, I/C intervention/control, IV intravenous, MTS maximum tetanus severity score, MICU medical intensive care unit, Mixed medical-surgical intensive care unit, MV mechanical ventilation, OD once daily, SAPS II simplified acute physiologic score II, SD standard deviation