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Table 4 Sensitivity analyses

From: Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial

  Early PN, € Late PN, € Mean difference (95% CI), € P value (t test)
N Mean SD p25–p75 N Mean SD p25–p75   
Primary analysis (total ICU costs and post-ICU hospitalisation costs) 670 33.860 57.600 11.080–34.720 673 26.680 35.850 10.090–28.830 -7.180 (-12.920; -1.880) 0.007
Sensitivity analyses
 1. Belgian unit pricesa 670 28.380 41.210 10.460–29.880 673 22.290 24.960 9.320–25.390 -6.090 (-9.950; -2.480) <0.001
 2. Dutch unit pricesb 670 37.960 62.120 12.570–38.350 673 29.270 37.180 11.560–32.390 -8.690 (-14.090; -3.190) 0.003
 3. Belgian patients 373 22.930 22.460 10.060–23.780 377 17.600 15.920 9.150–19.700 -5.330 (-8.650; -2.360) 0.003
 4. Dutch patients 297 47.580 78.820 14.860–46.410 296 38.250 48.630 12.790–42.380 -9.330 (-20.410; 1.250) 0.04
 5. Total ICU and total post-ICU costsc 670 34.990 58.316 11.470–35.580 673 27.800 36.859 10.530–30.580 -7.190 (-12.420; -1.970) 0.002
  1. PN parenteral nutrition, CI confidence interval, ICU Intensive Care Unit
  2. aThe total costs were analysed using prices from the Belgian healthcare system for all patients
  3. bThe total costs were analysed using prices from the Dutch healthcare system for all patients
  4. cIn the primary analysis, only the hospitalisation costs of the post-ICU period were included. The estimated additional post-ICU costs (i.e. laboratory, medication) were added. These additional post-ICU costs were estimated based on the invoices of the Belgian patients