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Table 3 Primary and secondary outcomes according to initial oxygenation group

From: Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study

Outcome

All subjects

n = 688

ED hypoxiaa

n = 38

ED normoxiab

n = 350

ED hyperoxiac

n = 300

Adjusted odds ratio or between-group difference (95% CI)

P value

Primary outcome, n (%)

 Mortality

162 (23.5)

5 (13.2)

68 (19.4)

89 (29.7)

1.95 (1.34–2.85)

<0.001

Secondary outcomes (days)

 Ventilator-free

16.5 (10.9)

20.3 (9.7)

17.9 (10.3)

14.2 (11.3)

3.7 (2.0–5.4)

<0.001

 ICU-free

15.2 (10.3)

17.9 (9.1)

16.7 (9.8)

13.2 (10.7)

3.5 (1.9–5.1)

<0.001

 Hospital-free

10.7 (9.2)

12.8 (9.3)

11.9 (9.0)

8.9 (9.1)

2.9 (1.5–4.3)

<0.001

  1. The P value for the primary outcome measure was from the Wald test estimated using a logistic regression model accounting for age, gender, Acute Physiology and Chronic Health Evaluation II score, lactate, emergency department tidal volume, emergency department (ED) plateau pressure, intensive care unit partial pressure of arterial oxygen (PaO2), and oxygen exposure group. The P values for the secondary outcomes are from the independent sample t test, comparing the normoxic and hyperoxic groups
  2. aPaO2 < 60 mm Hg
  3. bPaO2 60–120 mm Hg
  4. cPaO2 > 120 mm Hg