Skip to main content

Table 1 Baseline characteristics at the time of intubation

From: Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study

 

All subjects

n = 688

ED hypoxiaa

n = 38

ED normoxiab

n = 350

ED hyperoxiac

n = 300

P value

Age (years)

59.1 (16.0)

55.0 (16.7)

60.1 (14.7)

58.7 (17.1)

0.024

Female gender, n (%)

290 (42.2)

15 (39.5)

166 (47.4)

106 (35.3)

0.015

Race, n (%)

 Black

369 (53.6)

23 (60.5)

183 (52.3)

162 (54.0)

0.661

 White

317 (46.1)

15 (39.5)

164 (46.9)

134 (44.7)

 

 Other

7 (1.0)

0 (0)

3 (0.9)

4 (1.3)

 

Comorbidities, n (%)

 Chronic obstructive pulmonary disease

234 (34.0)

14 (36.8)

122 (34.9)

98 (32.7)

0.383

 Malignancy

117 (17.0)

8 (21.1)

57 (16.3)

52 (17.3)

0.655

 Congestive heart failure

189 (27.5)

10 (26.3)

92 (26.3)

86 (28.7)

0.893

 Diabetes mellitus

252 (36.6)

19 (50.0)

125 (35.7)

107 (35.7)

0.289

 End-stage renal disease

52 (7.6)

5 (13.2)

24 (6.9)

23 (7.7)

0.498

 Immunosuppression

61 (8.9)

6 (15.8)

33 (9.4)

22 (7.3)

0.287

 Cirrhosis

48 (7.0)

1 (2.6)

26 (7.4)

21 (7.0)

0.660

Indication for mechanical ventilation, n (%)

 Asthma

18 (2.6)

0

8 (2.3)

10 (3.3)

0.492

 Chronic obstructive pulmonary disease

77 (11.2)

4 (10.5)

39 (11.1)

34 (11.3)

 

 CHF/pulmonary edema

42 (6.1)

5 (13.2)

24 (6.9)

13 (4.3)

 

 Sepsis

237 (34.4)

17 (44.7)

117 (33.4)

102 (34.0)

 

 Trauma

119 (17.3)

6 (15.8)

58 (16.6)

53 (17.7)

 

 Cardiac arrest

42 (6.1)

1 (2.6)

17 (4.9)

24 (8.0)

 

 Drug overdose

29 (4.2)

1 (2.6)

13 (3.7)

15 (5.0)

 

 Other

129 (18.9)

4 (10.5)

74 (21.1)

49 (16.3)

 

APACHE II scored

16 (12–20)

19 (14–25)

16 (12–20)

15 (11–20)

0.011

Systolic blood pressure (mm Hg)

117 (94–145)

105 (75–148)

117 (97–145)

118 (95–144)

0.708

Vasopressor infusion, n (%)

178 (25.9)

15 (39.5)

85 (24.3)

77 (25.7)

0.238

Antibiotic administration, n (%)

332 (48.3)

23 (60.5)

177 (50.6)

131 (43.7)

0.068

Lactate (mmol/L)

2.3 (1.5–4.2)

3.0 (2.0–5.9)

2.2 (1.4–3.9)

2.3 (1.5–4.2)

0.047

Hemoglobin (g/dL)

12.1 (2.6)

12.1 (2.5)

12.1 (2.6)

12.0 (2.7)

0.335

Intravenous fluids in ED (L)

1.8 (1.8)

1.7 (1.5)

1.7 (1.8)

1.8 (1.8)

0.969

ED LOS (hours)

5.4 (3.5–7.9)

5.9 (3.8–8.4)

5.6 (3.7–8.1)

5.3 (3.5–7.5)

0.985

  1. Continuous variables are reported as mean (standard deviation) and median (interquartile range). P values are from the chi-square test for categorical variables, one-way analysis of variance for continuous variables, and the Kruskal-Wallis test (lactate, Acute Physiology and Chronic Health Evaluation (APACHE)). Bonferroni correction: α/n of comparisons = 0.05/3 = 0.017. CHF congestive heart failure, LOS length of stay, ED emergency department
  2. aPartial pressure of arterial oxygen (PaO2) <60 mmHg
  3. bPaO2 60–120 mmHg
  4. cPaO2 > 120 mmHg
  5. dModified score, which excludes the Glasgow Coma Scale