| All subjects n = 688 | ED hypoxiaa n = 38 | ED normoxiab n = 350 | ED hyperoxiac n = 300 | P value |
---|---|---|---|---|---|
Age (years) | 59.1 (16.0) | 55.0 (16.7) | 60.1 (14.7) | 58.7 (17.1) | 0.024 |
Female gender, n (%) | 290 (42.2) | 15 (39.5) | 166 (47.4) | 106 (35.3) | 0.015 |
Race, n (%) | |||||
 Black | 369 (53.6) | 23 (60.5) | 183 (52.3) | 162 (54.0) | 0.661 |
 White | 317 (46.1) | 15 (39.5) | 164 (46.9) | 134 (44.7) |  |
 Other | 7 (1.0) | 0 (0) | 3 (0.9) | 4 (1.3) |  |
Comorbidities, n (%) | |||||
 Chronic obstructive pulmonary disease | 234 (34.0) | 14 (36.8) | 122 (34.9) | 98 (32.7) | 0.383 |
 Malignancy | 117 (17.0) | 8 (21.1) | 57 (16.3) | 52 (17.3) | 0.655 |
 Congestive heart failure | 189 (27.5) | 10 (26.3) | 92 (26.3) | 86 (28.7) | 0.893 |
 Diabetes mellitus | 252 (36.6) | 19 (50.0) | 125 (35.7) | 107 (35.7) | 0.289 |
 End-stage renal disease | 52 (7.6) | 5 (13.2) | 24 (6.9) | 23 (7.7) | 0.498 |
 Immunosuppression | 61 (8.9) | 6 (15.8) | 33 (9.4) | 22 (7.3) | 0.287 |
 Cirrhosis | 48 (7.0) | 1 (2.6) | 26 (7.4) | 21 (7.0) | 0.660 |
Indication for mechanical ventilation, n (%) | |||||
 Asthma | 18 (2.6) | 0 | 8 (2.3) | 10 (3.3) | 0.492 |
 Chronic obstructive pulmonary disease | 77 (11.2) | 4 (10.5) | 39 (11.1) | 34 (11.3) |  |
 CHF/pulmonary edema | 42 (6.1) | 5 (13.2) | 24 (6.9) | 13 (4.3) |  |
 Sepsis | 237 (34.4) | 17 (44.7) | 117 (33.4) | 102 (34.0) |  |
 Trauma | 119 (17.3) | 6 (15.8) | 58 (16.6) | 53 (17.7) |  |
 Cardiac arrest | 42 (6.1) | 1 (2.6) | 17 (4.9) | 24 (8.0) |  |
 Drug overdose | 29 (4.2) | 1 (2.6) | 13 (3.7) | 15 (5.0) |  |
 Other | 129 (18.9) | 4 (10.5) | 74 (21.1) | 49 (16.3) |  |
APACHE II scored | 16 (12–20) | 19 (14–25) | 16 (12–20) | 15 (11–20) | 0.011 |
Systolic blood pressure (mm Hg) | 117 (94–145) | 105 (75–148) | 117 (97–145) | 118 (95–144) | 0.708 |
Vasopressor infusion, n (%) | 178 (25.9) | 15 (39.5) | 85 (24.3) | 77 (25.7) | 0.238 |
Antibiotic administration, n (%) | 332 (48.3) | 23 (60.5) | 177 (50.6) | 131 (43.7) | 0.068 |
Lactate (mmol/L) | 2.3 (1.5–4.2) | 3.0 (2.0–5.9) | 2.2 (1.4–3.9) | 2.3 (1.5–4.2) | 0.047 |
Hemoglobin (g/dL) | 12.1 (2.6) | 12.1 (2.5) | 12.1 (2.6) | 12.0 (2.7) | 0.335 |
Intravenous fluids in ED (L) | 1.8 (1.8) | 1.7 (1.5) | 1.7 (1.8) | 1.8 (1.8) | 0.969 |
ED LOS (hours) | 5.4 (3.5–7.9) | 5.9 (3.8–8.4) | 5.6 (3.7–8.1) | 5.3 (3.5–7.5) | 0.985 |