Table 2 Performance of cardiovascular biomarkers measured at ICU discharge for the prediction of 1-year post-ICU survival

Normal value

< 300

< 14

< 43

< 23.6 for men/< 16.0 for women

  All patients (n = 1570)

541 (149; 2073)

11.2 (4.2; 39.2)

33.3 (20.2; 60.5)

122.2 (73.1; 208.8)

  1-year survivor (n = 1237)

464 (127; 1681)

9.7 (3.7; 33.8)

30.5 (18.7; 52.3)

112.5 (67.9; 188.6)

  1-year nonsurvivor (n = 333)

1471 (371; 5719)

18.5 (7.6; 74.7)

50.4 (28.5; 107.9)

189.1 (102.4; 301.2)

  Univariate analysis

2.50 (1.85–3.38)

2.03 (1.51–2.73)

2.52 (1.86–3.42)

2.44 (1.81–3.30)

  Multivariable analysis

2.05 (1.33–3.18)

1.41 (0.94–2.13)

1.61 (1.06–2.45)

1.53 (1.01–2.33)

  Biomarker alone

0.659 (0.619–0.699)*

0.625 (0.588–0.663)*

0.672 (0.635–0.711)*

0.657 (0.618–0.697)*

  Biomarker + clinical score

0.794 (0.766–0.823)**

0.789 (0.759–0.817)

0.794 (0.766–0.822)

0.800 (0.773–0.827)**

  % Events to higher risk

44.3

37.4

43.4

42.5

  % Nonevents to higher risk

14.8

16.1

15.7

17.2

  % Events to lower risk

55.7

62.6

56.6

57.5

  % Nonevents to lower risk

85.2

83.9

84.3

82.8

  Total NRI for events (95% CI)

−0.115 (−0.263 to 0.033)

−0.253 (−0.397 to −0.109)

−0.133 (−0.281 to 0.015)

−0.149 (−0.296 to −0.003)

  Total NRI for nonevents (95% CI)

0.705 (0.650–0.759)

0.678 (0.622–0.734)

0.686 (0.631–0.742)

0.656 (0.598–0.714)

  Total cNRI (95% CI)

0.590 (0.433–0.747)

0.425 (0.271–0.580)

0.554 (0.396–0.711)

0.507 (0.349–0.664)

  Events to higher risk

0.014

–0.009

0.018

0.005

  Nonevents to lower risk

0.023

0.016

0.024

0.02

  Total (95% CI)

0.036 (0.019–0.054)

0.007 (0–0.014)

0.041 (0.023–0.06)

0.024 (0.009–0.04)