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Table 6 A two-stage approach to critical care

From: Time-sensitive therapeutics

• Rescue phase

 – Minimize demand and establish stability

 – Full support/gentle transitions

 – Take control (monotony may be needed)

• Adaptation phase

 – Intermittent stresses and rest periods

 – Ongoing targeted reductions of vital supports (acclimatize)

  – FiO2

  – Ventilating pressure

  – Vasopressors

  – Positioning

 – Encourage variability