Author (year) | Total number of cases | BP effects directly associated with Ang II | Cases with combined effect (Ang II + other) | Disclosed effects in cases with combined medication (Ang II + other) |
---|---|---|---|---|
Del Greco (1961) [25] | 20 | 17 | 3 | All three patients with initial BP 0/0 (cardiac arrest). 2/3 had no ROSC with addition of NE 54–200 mcg/min. 1/3 had ROSC with addition of NE at unknown dose, resulting in BP 100/0. |
Nassif (1963) [34] | 14 | 14 | 0 | - |
Wedeena (1963) [35] | 15 | 7 | 0 | Data available for only the 7 who responded. In these 7, NE was discontinued before Ang II started. |
Beanlands (1964) [36] | 17 | 13 | 4 | All 4 patients received concomitant EPI 2–4 mcg/min. |
Udhojia (1964) [26] | 12 | 6 | 0 | Data only available for 6 patients in whom Ang II was used alone. |
Belle (1965) [37] | 1 | 1 | 0 | Co-administered with metaraminol (unknown dose) with hypotension on metaraminol alone. BP rose as direct result of Ang II |
Cohn (1965) [27] | 6 | 6 | 0 | 3 of 6 patients received NE before Ang II dose but NE was turned off prior to Ang II administration. |
Cohn (1965) [27] | 22 | 22 | 0 | - |
Singh (1966) [28] | 25 | 25 | 0 | - |
Wallace (1967) [29] | 7 | 7 | 0 | - |
Sorensen (1986) [32] | 8 | 8 | 0 | - |
Moore (1989) [33] | 9 | 9 | 0 | - |
Geary (1990) [38] | 1 | 1 | 0 | - |
Thacker (1990) | 2 | 0 | 2 | 1 patient received PHENYL (unknown dose), NE 3 mcg/kg/min, an EPI bolus (unknown dose) and DOPA 5 mcg/kg/min plus Ang II. 1 patient received DOPA 5 mcg/kg/min, EPI 4 mcg/min, PHENYL (unknown dose), and NE 3mcg/kg/min plus Ang II. |
Thomas (1991) [40] | 1 | 1 | 0 | Co-administered with DOPA 6 mcg/kg/min, dobutamine (unknown dose), and NE 17 mcg/kg/min, but BP effect seen only after Ang II administration. |
Jackson (1993) [20] | 1 | 1 | 0 | Co-administered with DOPA 3 mcg/kg/min and EPI 0.02 mcg/kg/min, but BP only responded after administration of Ang II. |
Trilli (1994) [21] | 1 | 1 | 0 | Co-administered with DOPA 20mcg/kg/min, dobutamine (unknown dose), and NE 14.5mcg/min, but upon initiation of Ang II NE dose declined to 7mcg/min. |
Ryding (1995) [41] | 1 | 1 | 0 | Co-administered with DOPA 4 mcg/kg/min, dobutamine (unknown dose), and NE at 28mcg/min, which were all titrated off after administration of Ang II and amrinone (unknown dose). |
Newby (1995) [22] | 1 | 1 | 0 | Co-administered with DOPA 2.5 mcg/kg/min and NE 1Â mg bolus, but BP only responded after Ang II administration. |
Wray (1995) [24] | 1 | 1 | 0 | Co-administered with NE 8.3 mcg/kg/min and DOPA (low unknown dose), but BP only responded after administration of Ang II. |
Tovar (1997) [23] | 1 | 1 | 0 | Co-administered with DOPA 4.9 mcg/kg/min and NE 60 mcg/min. BP only responded to addition of Ang II, which caused DOPA and NE to be turned off, both of which had to be restarted with Ang II cessation. |
Eyraud (1998) [30] | 14 | 14 | 0 | - |
Chawla (2014) [10] | 10 | 10 | 0 | Co-administered with VASO 0.02–0.08 u/min and NE 7.3–7.4 mcg/min. NE dose fell from a baseline 19.8 mcg/min upon initiation of Ang II. |
Khannab (2017) [11] | 163 | 163 | 0 | Co-administered with a NE equivalent of 0.45 mcg/kg/min ranging down to 0.4 mcg/kg/min during 3Â hours of Ang II administration, with positive BP effect seen at 3Â hours, per study protocol. |
Total | 353 | 330 | 9 | Â |