Table 2 Blood pressure effect of Ang II versus other vasoactive medications

Del Greco (1961) [25]

20

17

3

All three patients with initial BP 0/0 (cardiac arrest). 2/3 had no ROSC with addition of NE 54–200 mcg/min. 1/3 had ROSC with addition of NE at unknown dose, resulting in BP 100/0.

Nassif (1963) [34]

14

14

0

-

Wedeen^a (1963) [35]

15

7

0

Data available for only the 7 who responded. In these 7, NE was discontinued before Ang II started.

Beanlands (1964) [36]

17

13

4

All 4 patients received concomitant EPI 2–4 mcg/min.

Udhoji^a (1964) [26]

12

6

0

Data only available for 6 patients in whom Ang II was used alone.

Belle (1965) [37]

1

1

0

Co-administered with metaraminol (unknown dose) with hypotension on metaraminol alone. BP rose as direct result of Ang II

Cohn (1965) [27]

6

6

0

3 of 6 patients received NE before Ang II dose but NE was turned off prior to Ang II administration.

Cohn (1965) [27]

22

22

0

-

Singh (1966) [28]

25

25

0

-

Wallace (1967) [29]

7

7

0

-

Sorensen (1986) [32]

8

8

0

-

Moore (1989) [33]

9

9

0

-

Geary (1990) [38]

1

1

0

-

Thacker (1990)

2

0

2

1 patient received PHENYL (unknown dose), NE 3 mcg/kg/min, an EPI bolus (unknown dose) and DOPA 5 mcg/kg/min plus Ang II. 1 patient received DOPA 5 mcg/kg/min, EPI 4 mcg/min, PHENYL (unknown dose), and NE 3mcg/kg/min plus Ang II.

Thomas (1991) [40]

1

1

0

Co-administered with DOPA 6 mcg/kg/min, dobutamine (unknown dose), and NE 17 mcg/kg/min, but BP effect seen only after Ang II administration.

Jackson (1993) [20]

1

1

0

Co-administered with DOPA 3 mcg/kg/min and EPI 0.02 mcg/kg/min, but BP only responded after administration of Ang II.

Trilli (1994) [21]

1

1

0

Co-administered with DOPA 20mcg/kg/min, dobutamine (unknown dose), and NE 14.5mcg/min, but upon initiation of Ang II NE dose declined to 7mcg/min.

Ryding (1995) [41]

1

1

0

Co-administered with DOPA 4 mcg/kg/min, dobutamine (unknown dose), and NE at 28mcg/min, which were all titrated off after administration of Ang II and amrinone (unknown dose).

Newby (1995) [22]

1

1

0

Co-administered with DOPA 2.5 mcg/kg/min and NE 1 mg bolus, but BP only responded after Ang II administration.

Wray (1995) [24]

1

1

0

Co-administered with NE 8.3 mcg/kg/min and DOPA (low unknown dose), but BP only responded after administration of Ang II.

Tovar (1997) [23]

1

1

0

Co-administered with DOPA 4.9 mcg/kg/min and NE 60 mcg/min. BP only responded to addition of Ang II, which caused DOPA and NE to be turned off, both of which had to be restarted with Ang II cessation.

Eyraud (1998) [30]

14

14

0

-

Chawla (2014) [10]

10

10

0

Co-administered with VASO 0.02–0.08 u/min and NE 7.3–7.4 mcg/min. NE dose fell from a baseline 19.8 mcg/min upon initiation of Ang II.

Khanna^b (2017) [11]

163

163

0

Co-administered with a NE equivalent of 0.45 mcg/kg/min ranging down to 0.4 mcg/kg/min during 3 hours of Ang II administration, with positive BP effect seen at 3 hours, per study protocol.

Total

353

330

9