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Table 3 Association of early (day 0) hyaluronic acid levels with components of LIS

From: Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome

Lung injury score componenta

Source

β (95% CI)b

p

β (95% CI)c

p

Chest radiographd

Serum

-0.15 (-0.54–0.24)

0.44

-0.25 (-0.63–0.14)

0.21

BALFe

-0.05 (-0.30–0.20)

0.69

-0.08 (-0.33–0.17)

0.53

Hypoxemiaf

Serum

0.66 (0.19–1.12)

0.006

0.57 (0.11–1.03)

0.02

BALFe

0.57 (0.28–0.86)

<0.001

0.56 (0.28–0.85)

<0.001

Positive end-expiratory pressure

Serum

0.77 (0.16–1.38)

0.01

0.76 (0.16–1.35)

0.01

BALFe

0.57 (0.17–0.96)

0.006

0.46 (0.07–0.85)

0.02

Respiratory system complianceg

Serum

0.005 (-0.35–0.36)

0.98

0.02 (-0.31–0.36)

0.89

BALFe

0.09 (-0.14–0.32)

0.43

0.04 (-0.17–0.26)

0.69

  1. LIS lung injury score, BALF bronchoalveolar fluid
  2. aSee Additional file 1: Table S1 for scoring of composite LIS via individual end-organ components
  3. bLinear regression between log10-transformed day-0 hyaluronic acid concentration and respective outcome measure (in units of LIS)
  4. cMultiple linear regression adjusted for age, sex, race, treatment group, and acute respiratory distress syndrome etiology
  5. dOne patient did not have a chest radiograph available to interpret
  6. eTwo patients did not have day-0 BALF samples (n = 84)
  7. fTwo patients did not have blood gas data available (n = 84)
  8. gNine patients did not have compliance data available (n = 77)