Skip to main content

Table 2 Association of early (day 0) hyaluronic acid levels with degree of end organ dysfunction

From: Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome

Outcome

Source

β (95% CI)a

p

β (95% CI)b

p

Lung injury score

Serum

0.35 (0.05–0.65)

0.02

0.30 (0.02–0.57)

0.04

BALFc

0.31 (0.11–0.50)

0.002

0.27 (0.09–0.45)

0.003

Ventilator-free daysd

Serum

-0.59 (-1.21–0.03)

0.06

-0.47 (-1.10–0.15)

0.14

BALFc

-0.09 (-0.51–0.33)

0.67

-0.15 (-0.58–0.27)

0.47

SOFAe

Serum

3.89 (2.18–5.61)

<0.001

4.02 (2.30–5.74)

<0.001

BALFc

0.42 (-0.85–1.69)

0.52

0.72 (-0.56–2.00)

0.27

  1. SOFA sequential organ failure assessment score, BALF bronchoalveolar fluid,
  2. aLinear regression between log10-transformed day-0 hyaluronic acid concentration and respective outcome measure (in units of lung injury score, quartiles of ventilator-free days, or units of SOFA)
  3. bMultiple linear regression adjusted for age, sex, race, treatment group, and acute respiratory distress syndrome etiology
  4. cTwo patients did not have day-0 BALF samples (n = 84)
  5. dVentilator-free days were analyzed as quartiles, given the skewed distribution