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Table 3 Protein kinetics (phenylalanine)

From: A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients

  Balance (μmol/kg/h) Breakdown (μmol/kg/h) Synthesis (μmol/kg/h) Oxidation (μmol/kg/h) Serum urea (mmol/L) Plasma AA (μmol/L)
BL–3 h–24 h (n = 8)
 ANOVAa 0.0016 0.500 0.292 0.147 0.053 0.038
 BL -1.6 ± 7.4 61.8 ± 14.0 60.2 (53.6-68.2) 13.7 (10.8-15.0) 13.8 ± 8.4 3064 ± 636
 3 h 6.0 ± 8.8 65.4 ± 21.9 71.4 ± 17.4 17.0 ± 6.4 13.8 ± 8.1 3229 ± 295
 24 h 7.5 ± 5.1 56.4 ± 13.6 63.9 ± 13.4 12.7 ± 3.5 15.4 (10.5-17.7) 3599 ± 494
p valueb BL–3 h (95% CI) p = 0.01 (1.74–13.57)      p = 1.00 (-350–679)
p valueb BL–24 h (95% CI) p = 0.0027 (3.21–15.04)      p = 0.0405 (20–1049)
p valueb 3 h–24 h (95% CI) p = 1.00 (-4.44–7.39)      p = 0.213 (-144–884)
BL–3 h (n = 11)
 BL -1.7 ± 7.0 63.2 ± 16.6 61.6 ± 14.5 14.0 ± 4.8 13.1 ± 7.5 3030 ± 619
 3 h 5.7 ± 8.2 65.7 ± 20.3 71.5 ± 18.1 17.5 ± 6.0 13.2 ± 7.1 3289 ± 442
p value (95% CI) p = 0.002 (3.27–11.48) p = 0.649 (-9.06–13.89) p = 0.064 (-0.68–20.56) p = 0.097 (-0.76–7.74) p = 0.266 (-0.15–0.50) p = 0.073 (-29–547)
BL–24 h (n = 9)
 BL -1.8 ± 7.0 60.4 ± 13.7 58.6 ± 8.5 13.4 (10.7–14.2) 12.9 ± 8.3 2992 ± 633
 24 h 6.9 ± 5.1 55.1 ± 13.3 62.0 ± 13.7 12.8 ± 3.3 14.4 (8.6–16.8) 3503 ± 544
p value (95% CI) p < 0.001 (5.4–11.99) p = 0.266 (-15.49–4.91) p = 0.387 (-5.19–12.02) p = 0.859c p = 0.051c p = 0.046 (12–1009)
  1. Normally distributed data presented as means ± SD, non-normal data as median (IQR). Kg denotes actual body weight
  2. BL baseline, ANOVA analysis of variance, AA amino acids, CI confidence interval
  3. aOne-way ANOVA for repeated measures. Sphericity assessed with Mauchly’s test of sphericity. Greenhouse-Geisser correction applied when appropriate
  4. bPairwise comparisons, Bonferroni post-hoc test
  5. cWilcoxon signed-rank test