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Table 3 Protein kinetics (phenylalanine)

From: A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients

 

Balance (μmol/kg/h)

Breakdown (μmol/kg/h)

Synthesis (μmol/kg/h)

Oxidation (μmol/kg/h)

Serum urea (mmol/L)

Plasma AA (μmol/L)

BL–3 h–24 h (n = 8)

 ANOVAa

0.0016

0.500

0.292

0.147

0.053

0.038

 BL

-1.6 ± 7.4

61.8 ± 14.0

60.2 (53.6-68.2)

13.7 (10.8-15.0)

13.8 ± 8.4

3064 ± 636

 3 h

6.0 ± 8.8

65.4 ± 21.9

71.4 ± 17.4

17.0 ± 6.4

13.8 ± 8.1

3229 ± 295

 24 h

7.5 ± 5.1

56.4 ± 13.6

63.9 ± 13.4

12.7 ± 3.5

15.4 (10.5-17.7)

3599 ± 494

p valueb BL–3 h (95% CI)

p = 0.01 (1.74–13.57)

    

p = 1.00 (-350–679)

p valueb BL–24 h (95% CI)

p = 0.0027 (3.21–15.04)

    

p = 0.0405 (20–1049)

p valueb 3 h–24 h (95% CI)

p = 1.00 (-4.44–7.39)

    

p = 0.213 (-144–884)

BL–3 h (n = 11)

 BL

-1.7 ± 7.0

63.2 ± 16.6

61.6 ± 14.5

14.0 ± 4.8

13.1 ± 7.5

3030 ± 619

 3 h

5.7 ± 8.2

65.7 ± 20.3

71.5 ± 18.1

17.5 ± 6.0

13.2 ± 7.1

3289 ± 442

p value (95% CI)

p = 0.002 (3.27–11.48)

p = 0.649 (-9.06–13.89)

p = 0.064 (-0.68–20.56)

p = 0.097 (-0.76–7.74)

p = 0.266 (-0.15–0.50)

p = 0.073 (-29–547)

BL–24 h (n = 9)

 BL

-1.8 ± 7.0

60.4 ± 13.7

58.6 ± 8.5

13.4 (10.7–14.2)

12.9 ± 8.3

2992 ± 633

 24 h

6.9 ± 5.1

55.1 ± 13.3

62.0 ± 13.7

12.8 ± 3.3

14.4 (8.6–16.8)

3503 ± 544

p value (95% CI)

p < 0.001 (5.4–11.99)

p = 0.266 (-15.49–4.91)

p = 0.387 (-5.19–12.02)

p = 0.859c

p = 0.051c

p = 0.046 (12–1009)

  1. Normally distributed data presented as means ± SD, non-normal data as median (IQR). Kg denotes actual body weight
  2. BL baseline, ANOVA analysis of variance, AA amino acids, CI confidence interval
  3. aOne-way ANOVA for repeated measures. Sphericity assessed with Mauchly’s test of sphericity. Greenhouse-Geisser correction applied when appropriate
  4. bPairwise comparisons, Bonferroni post-hoc test
  5. cWilcoxon signed-rank test