| |
Balance (μmol/kg/h)
|
Breakdown (μmol/kg/h)
|
Synthesis (μmol/kg/h)
|
Oxidation (μmol/kg/h)
|
Serum urea (mmol/L)
|
Plasma AA (μmol/L)
|
|---|
|
BL–3 h–24 h (n = 8)
|
|
ANOVAa
|
0.0016
|
0.500
|
0.292
|
0.147
|
0.053
|
0.038
|
|
BL
|
-1.6 ± 7.4
|
61.8 ± 14.0
|
60.2 (53.6-68.2)
|
13.7 (10.8-15.0)
|
13.8 ± 8.4
|
3064 ± 636
|
|
3 h
|
6.0 ± 8.8
|
65.4 ± 21.9
|
71.4 ± 17.4
|
17.0 ± 6.4
|
13.8 ± 8.1
|
3229 ± 295
|
|
24 h
|
7.5 ± 5.1
|
56.4 ± 13.6
|
63.9 ± 13.4
|
12.7 ± 3.5
|
15.4 (10.5-17.7)
|
3599 ± 494
|
|
p valueb BL–3 h (95% CI)
|
p = 0.01 (1.74–13.57)
| | | | |
p = 1.00 (-350–679)
|
|
p valueb BL–24 h (95% CI)
|
p = 0.0027 (3.21–15.04)
| | | | |
p = 0.0405 (20–1049)
|
|
p valueb 3 h–24 h (95% CI)
|
p = 1.00 (-4.44–7.39)
| | | | |
p = 0.213 (-144–884)
|
|
BL–3 h (n = 11)
|
|
BL
|
-1.7 ± 7.0
|
63.2 ± 16.6
|
61.6 ± 14.5
|
14.0 ± 4.8
|
13.1 ± 7.5
|
3030 ± 619
|
|
3 h
|
5.7 ± 8.2
|
65.7 ± 20.3
|
71.5 ± 18.1
|
17.5 ± 6.0
|
13.2 ± 7.1
|
3289 ± 442
|
|
p value (95% CI)
|
p = 0.002 (3.27–11.48)
|
p = 0.649 (-9.06–13.89)
|
p = 0.064 (-0.68–20.56)
|
p = 0.097 (-0.76–7.74)
|
p = 0.266 (-0.15–0.50)
|
p = 0.073 (-29–547)
|
|
BL–24 h (n = 9)
|
|
BL
|
-1.8 ± 7.0
|
60.4 ± 13.7
|
58.6 ± 8.5
|
13.4 (10.7–14.2)
|
12.9 ± 8.3
|
2992 ± 633
|
|
24 h
|
6.9 ± 5.1
|
55.1 ± 13.3
|
62.0 ± 13.7
|
12.8 ± 3.3
|
14.4 (8.6–16.8)
|
3503 ± 544
|
|
p value (95% CI)
|
p < 0.001 (5.4–11.99)
|
p = 0.266 (-15.49–4.91)
|
p = 0.387 (-5.19–12.02)
|
p = 0.859c
|
p = 0.051c
|
p = 0.046 (12–1009)
|
- Normally distributed data presented as means ± SD, non-normal data as median (IQR). Kg denotes actual body weight
-
BL baseline, ANOVA analysis of variance, AA amino acids, CI confidence interval
-
aOne-way ANOVA for repeated measures. Sphericity assessed with Mauchly’s test of sphericity. Greenhouse-Geisser correction applied when appropriate
-
bPairwise comparisons, Bonferroni post-hoc test
-
cWilcoxon signed-rank test
