Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score)

Table 2 Assessment of prediction scores

	Total	Survivors	Non-survivors	AUC	95% CI	p value	Hosmer–Lemeshow statistic (χ²; p value)	Pairwise comparison to PRESET-Score (difference between areas; p value)
Derivation cohort (n)	108	41	67
ECMOnet-Score	4.5 (3; 6)	4 (3; 5)	5 (4; 7)	0.695	0.59–0.79	0.001	3.7; 0.876	0.127; 0.0260
RESP-Score	–1 (–6; 3)	1 (–3; 4)	–2 (–7; 2)	0.645	0.53–0.75	0.012	8.4; 0.395	0.178; 0.0045
PRESERVE-Score	4 (3; 6)	4 (2; 5)	5 (3; 6)	0.593	0.48–0.71	0.106	5.2; 0.396	0.230; 0.0010
Roch-Score	3 (3; 4)	3 (2; 4)	3 (3; 4)	0.564	0.45–0.68	0.269	5.4; 0.020	0.259; 0.0003
PRESET-Score	7 (5; 10)	5 (4; 7)	8 (7; 11)	0.823	0.74–0.90	< 0.001	2.9; 0.940
Internal validation cohort (n)	82	37	45
PRESET-Score	6 (5; 10)	4 (4; 6)	8 (6; 11)	0.845	0.76–0.93	< 0.001	10.9; 0.207
External validation cohort (n)	59	31	28
PRESET-Score	7 (5; 9)	6 (4; 8)	8 (7; 10)	0.700	0.56–0.83	0.008	4.2; 0.655

Variables presented as median (first quartile; third quartile)
ARDS acute respiratory distress syndrome, AUC area under the curve, CI confidence interval, ECMO extracorporeal membrane oxygenation, PRESERVE-Score Predicting Death for Severe ARDS on VV-ECMO, PRESET-Score PREdiction of Survival on ECMO Therapy-Score, VV veno-venous

ISSN: 1364-8535