Fig. 4
From: Complications of regional citrate anticoagulation: accumulation or overload?
Theoretical relationship between blood citrate level and citrate load. a An increase in citrate load is not associated with an increase in blood citrate level until a threshold is reached. This threshold corresponds to the body’s capacity to metabolize citrate. b Certain circumstances, such as severe liver failure or circulatory shock, might result in a lower threshold corresponding to a decreased capacity to metabolize citrate (see text)