Vitamin D deficiency in critically ill children: a systematic review and meta-analysis

Table 4 Relationship between vitamin D deficiency status and markers of illness severity and intensive care unit outcome

ICU outcome or intervention	Pooled OR (95% CI)
ICU outcome or intervention	All studies	Developed countries	Developing countries	p Value^a
Mortality	1.62 (1.08–2.44)	2,52 (1.37–4.60)	1.12 (0.71–1.78)	0.04
Mechanical ventilation	1.83 (1.28–2.63)	1.92 (1.23–3.01)	1.69 (0.85–3.37)	0.74
Vasopressor use	1.97 (1.49–2.61)	2.22 (1.54–3.21)	1.52 (0.93–2.50)	0.29
Infection (bacterial/nosocomial)	2.21 (1.50–3.25)	2.49 (1.41–4.38)	1.77 (0.94–3.33)	0.55

Pooled OR from random effects meta-analysis evaluating the relationship between vitamin D status and established markers of illness severity, intervention, and outcome in the pediatric intensive care unit setting
^aMetaregression was used to evaluate whether the pooled ORs were statistically different between developed and developing countries

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