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Table 1 Baseline characteristics for patients according to worst KeGFR in the first 7 days of ICU stay

From: Kinetic estimated glomerular filtration rate in critically ill patients: beyond the acute kidney injury severity classification system

 

Total patients (n = 13,284)

Lowest KeGFR > 70 ml/min/1.73 m2 (n = 7,089)

Lowest KeGFR 45–70 ml/min/1.73 m2 (n = 3,420)

Lowest KeGFR 30–45 ml/min/1.73 m2 (n = 1,112)

Lowest KeGFR < 30 ml/min/1.73 m2 (n = 1,663)

p

Age (years), mean ± SD

63.3 ± 17.3

60.3 ± 17.3

66.8 ± 16.6

69.5 ± 15.2

64.6 ± 17.0

<0.001

Male, n (%)

7067 (53.2)

3850 (54.3)

1772 (51.8)

596 (53.6)

849 (51.0)

0.196

Hypertension, n (%)

4076 (30.7)

2349 (33.1)

1073 (31.4)

311 (28.0)

343 (20.6)

<0.001

Uncomplicated diabetes, n (%)

2477 (18.6)

1294 (18.2)

676 (19.8)

238 (21.4)

269 (16.2)

0.001

Complicated diabetes, n (%)

604 (4.5)

175 (2.5)

208 (6.1)

69 (6.2)

152 (9.1)

<0.001

Obesity, n (%)

205 (1.5)

102 (1.4)

54 (1.6)

16 (1.4)

32 (1.9)

0.084

Congestive heart failure, n (%)

2566 (19.3)

1051 (14.8)

762 (22.3)

289 (26.0)

464 (27.9)

<0.001

COPD, n (%)

2054 (15.5)

1045 (14.7)

567 (16.6)

190 (17.1)

252 (15.1)

0.087

Cardiac arrhythmia, n (%)

2414 (18.2)

1180 (16.6)

672 (19.6)

224 (20.1)

338 (20.3)

<0.001

Liver disease, n (%)

727 (5.5)

334(4.7)

155(4.5)

82 (7.4)

156 (9.4)

<0.001

Metastatic cancer, n (%)

620 (4.7)

333 (4.7)

167 (4.9)

39 (3.5)

81 (4.9)

0.197

Surgical patients, n (%)

5275 (39.7)

2746 (38.7)

1512 (44.2)

471 (42.4)

546 (32.8)

<0.001

Sepsis, n (%)

3964 (29.8)

1666 (23.5)

1084 (31.7)

415 (37.3)

799 (48.0)

<0.001

SAPS II on ICU admission, median (IQR)

33 (24–41)

29 (22–38)

34 (27–43)

38 (30–47)

40 (31–49)

<0.001

SOFA on ICU admission, median (IQR)

6 (3–9)

5 (3–8)

7 (3–9)

8 (4–11)

9 (5–12)

<0.001

Baseline eGFR* (ml/min), mean ± SD

109.0 ± 33.9

129.0 ± 38.8

97.5 ± 29.9

80.9 ± 26.0

64.4 ± 34.7

<0.001

Vasopressors, n (%)

4793 (36.1)

2035 (28.7)

1377 (40.3)

539 (48.5)

842 (50.6)

<0.001

Mechanical ventilation, n (%)

8484 (63.9)

4022 (56.7)

2359 (69.0)

837 (75.3)

1266 (76.1)

<0.001

Lowest KeGFR during first 7 days of ICU stay (ml/min), mean ± SD

66.4 ± 29.1

88.2 ± 15.7

56.3 ± 7.2

34.5 ± 4.3

15.6 ± 8.1

<0.001

ICU LOS (days), median (IQR)

3.3 (2.1–6.1)

2.8 (1.8–4.8)

3.7 (2.3–6.9)

4.3 (2.6–7.7)

5.3(3.1–10.2)

<0.001

Hospital LOS (days), median (IQR)

9 (6–15)

8 (4–13)

9 (6–16)

11 (7–18)

12 (8–21)

<0.001

ICU mortality, n (%)

1,023 (7.7)

275 (3.9)

253 (7.4)

134 (12.0)

361 (22.7)

<0.001

Inhospital mortality, n (%)

1,562 (11.8)

499 (7.0)

420 (12.2)

180 (16.2)

463 (27.8)

<0.001

  1. *Using lowest serum creatinine during ICU stay
  2. COPD chronic obstructive pulmonary disease, eGFR estimated glomerular filtration rate, ICU intensive care unit, IQR interquartile range, KeGFR kinetic estimated glomerular filtration rate, LOS length of stay, SAPS II Simplified Acute Physiology Score II, SD standard deviation, SOFA Sequential Organ Failure Assessment