|
28-Day outcomes
|
sHR (95% CI)
|
P value
|
|---|
|
Invasive mechanical ventilation
| |
<0.0001
|
|
No nutrition
|
1.0
| |
|
Parenteral nutrition
|
1.7 (1.0–2.7)
|
0.04
|
|
Enteral nutrition
|
2.1 (1.1–4.2)
|
0.03
|
|
Oral nutrition
|
0.5 (0.3–0.7)
|
0.0005
|
| |
HR (95% CI)
|
P value
|
|
Mortality
| |
0.02
|
|
No nutrition
|
1.0
| |
|
Parenteral nutrition
|
1.3 (0. 7–2.2)
|
0.39
|
|
Enteral nutrition
|
2.3 (1.2–4.4)
|
0.01
|
|
Oral nutrition
|
0.8 (0.5–1.1)
|
0.20
|
| |
RR (95% CI)
|
P value
|
|
Ventilator-free days
| |
0.006
|
|
No nutrition
|
1.0
| |
|
Parenteral nutrition
|
0.9 (0.7–1.0)
|
0.11
|
|
Enteral nutrition
|
0.7 (0.5–0.9)
|
0.01
|
|
Oral nutrition
|
1.1 (1.0–1.2)
|
0.10
|
| |
sHR (95% CI)
|
P value
|
|
Nosocomial infectiona
| |
0.02
|
|
No nutrition
|
1.0
| |
|
Parenteral nutrition
|
1.0 (0.5–1.9)
|
0.96
|
|
Enteral nutrition
|
2.2 (1.1–4.5)
|
0.03
|
|
Oral nutrition
|
0.7 (0.5–1.0)
|
0.06
|
| |
sHR (95% CI)
|
P value
|
|
ICU-acquired pneumonia
| |
0.18
|
|
No nutrition
|
1.0
| |
|
Parenteral nutrition
|
1.1 (0.5–2.5)
|
0.75
|
|
Enteral nutrition
|
2.1 (0.8–5.4)
|
0.13
|
|
Oral nutrition
|
0.7 (0.4–1.2)
|
0.17
|
| |
sHR (95% CI)
|
P value
|
|
VAP
| |
0.002
|
|
No nutrition
|
1.0
| |
|
Parenteral nutrition
|
2.9 (1.1–7.4)
|
0.03
|
|
Enteral nutrition
|
6.9 (2.1– 22.3)
|
0.001
|
|
Oral nutrition
|
0.9 (0.4–2.1)
|
0.76
|
-
Abbreviations: sHR Subdistribution hazard ratio, ICU Intensive care unit, RR Relative risk, VAP Ventilator-associated pneumonia
- Results are given as HR for Cox models, RR for the negative binomial model, and subdistribution hazard ratio (sHR) for the Gray and Fine model. (i.e., age, sex, hospital length of stay before ICU admission < 2 days, acute illness severity at ICU admission [Sequential Organ Failure Assessment {SOFA} score], respiratory and neurologic SOFA subscores at ICU admission, obesity, chronic disease, and main diagnosis at ICU admission)
-
aNosocomial infection includes bacteremia, urinary tract infection, VAP, ICU-acquired pneumonia, central line-associated bloodstream infection
