Skip to main content

Table 2 Cefepime characteristics

From: Cefepime-induced neurotoxicity: a systematic review

Characteristic Value
Cefepime dosing
 Median dose over 24 hours (IQR), g 3.5 (2–5.9)
 Median frequency of dosing (IQR), hours 12 (12–24)
Appropriately dosed for renal function, n (%)
 No 65 (48%)
 Yes 35 (26%)
 Unable to assess 35 (26%)
Indication, n (%)
 Febrile neutropenia 11 (8%)
 Pneumonia 37 (27%)
 Othera 31 (23%)
 Not reported 56 (41%)
Drug concentrations, mg/L  
 Median serum, n = 21 (range) 45 (15–284)
 Median trough, n = 13 (range) 38 (15–224)
 Median CSF, n = 4 (range) 13 (6–18)
 Median for appropriately dosed patients, n = 7 (range) 60 (22–74)
 Median for inappropriately dosed patients, n = 10 (range) 39 (15–284)
 Trough for appropriately dosed patients, n = 6 (range) 54 L (37–65)
Median onset of neurotoxic effects (IQR), days 4 (2–6)
  1. CNS central nervous system
  2. aNo patients were treated for meningitis/CNS infections