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Table 1 Patient characteristics (n = 135)

From: Cefepime-induced neurotoxicity: a systematic review

Characteristic

Value

Median age (IQR)

69 years (54–75)

Sex (female), n (%)

69 (51%)

Pre-existing CNS disease, n (%)

11 (8%)

 Cerebral vascular disease

6 (4%)

 Encephalopathy

2 (1%)

 Othera

3 (2%)

Renal function dysfunction

108 (80%)

Creatinine clearance, median (IQR)

26.5 (17–56) ml/min

History of alcohol use disorder, n (%)

3 (2%)

Co-administered neurotoxic drug(s), n (%)b

21 (16%)

Patient location, n (%)

 ICU

60 (44%)

 Non-ICU

14 (10%)

 Unreported

61 (45%)

  1. CNS central nervous system
  2. aOther pre-existing CNS diseases included encephalitis, spina bifida, dementia
  3. bReported neurotoxic medications include amikacin, ciprofloxacin, metronidazole, cytarabine, cyclosporine, tacrolimus, phenytoin