Fig. 6

Vasculotide therapy (VT) did not relevantly alter the systemic inflammatory response in Streptococcus pneumoniae-infected mice. S. pneumoniae (5 × 10⁶ colony-forming units/mouse) or sham-infected mice were intravenously (i.v.) treated with VT (500 ng) or PBS 22 h, 34 h, and 46 h postinfection (p.i.). Mice were exsanguinated, and their lungs were prepared 24 h or 48 h p.i. Blood cells were differentiated, and plasma levels of interleukin (IL)-6 and KC were quantified. Subgroups of blood leukocytes did not differ between VT-treated and solvent (PBS)-treated mice with pneumonia 24 h (a) and 48 h (b) p.i. IL-6 plasma levels were significantly reduced after VT treatment 24 h p.i. (c) but did not differ between infected groups at 48 h p.i. (d). Values are given as mean + SEM (n = 8 for S. pneumoniae-infected groups or n = 5 for sham-infected groups). *p < 0.05 between indicated groups. PMN Polymorphonuclear cells, S. pn. Streptococcus pneumoniae