Table 3 Summary of main results of primary and secondary outcomes

Outcome analyzed

Studies

Patients

OR or SMD (95% CI)

p Value

I ² Statistic

p Value

Mortality overall

6

1728

OR 0.64 (0.37, 1.11)

0.11

42%

0.12

Mortality in low LVEF

5

1224

OR 0.51 (0.32, 0.82)

0.005

0%

0.66

Need for RRT overall

6

1728

OR 0.63 (0.42, 0.94)

0.02

0%

0.91

Need for RRT in low LVEF

5

1224

OR 0.55 (0.31, 0.97)

0.04

0%

0.90

AF and SVT overall

5

1695

OR 0.62 (0.32, 1.18)

0.15

79%

0.0007

AF and SVT in low LVEF

4

1141

OR 0.52 (0.19, 1.40)

0.20

84%

0.0003

Myocardial damage overall

4

1645

OR 0.89 (0.52, 1.53)

0.68

29%

0.24

Myocardial damage in low LVEF

3

1141

OR 0.60 (0.15, 2.41)

0.47

53%

0.12

Mechanical support overall

6

1728

OR 0.38 (0.13, 1.10)

0.07

82%

<0.0001

Mechanical support in low LVEF

5

1224

OR 0.29 (0.09, 1.00)

0.05

85%

<0.0001

Hypotension overall

5

1695

OR 1.41 (0.92, 2.18)

0.12

0%

0.54

Hypotension in low LVEF

4

1191

OR 1.31 (0.82, 2.08)

0.26

0%

0.52

LCOS in low LVEF

4

1191

OR 0.55 (0.38, 0.79)

0.001

9%

0.35

AKI (risk, injury, failure of RIFLE criteria)

3

817

OR 0.64 (0.44, 0.94)

0.02

9%

0.33

Duration of MV overall

3

567

SMD −0.11 (−0.28, 0.05)

0.18

0%

0.61

ICU LOS overall

4

1419

SMD −0.41 (−0.83, 0.02)

0.06

89%

<0.0001

ICU LOS in low LVEF

3

962

SMD −0.78 (−1.90, 0.34)

0.17

92%

<0.0001

Hospital LOS overall

3

567

SMD −0.73 (−1.89, 0.43)

0.22

93%

<0.0001