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Fig. 4 | Critical Care

Fig. 4

From: 6% Hydroxyethyl starch (HES 130/0.4) diminishes glycocalyx degradation and decreases vascular permeability during systemic and pulmonary inflammation in mice

Fig. 4

Hydroxyethyl starch (HES) 130/0.4 effects on vascular permeability during systemic inflammation. Wild-type mice underwent a sham or cecal ligation and puncture (CLP) operation (n = 8). Sixty minutes after the procedure, mice received 20 ml/kg Isolyte® (Iso) or HES 130/0.4 (HES) as an infusion over 1 h. At 4, 8, and 24 h after the operation, vascular permeability in the (a) lung, (b) liver, (c) kidney, and (d) brain was measured by photometry using the extravasation of Evans blue (EB) technique. (e) EB extravasation in CLP mice treated with 20 ml/kg Isolyte® (Iso), HES 130/0.4 (HES), or HES 130/0.4 plus 150 μg of N-desulfated/re-N-acetylated heparin (NAH) 24 h after CLP induction. Data are presented as mean ± SEM, * p < 0.05

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Critical Care

ISSN: 1364-8535