Table 1 Inclusion criteria for studies according PICOS
From: Aerosol delivery during invasive mechanical ventilation: a systematic review
| Participants | Adult aged 18 years or older with invasive mechanical ventilation |
| or in vivo experimental model of adult invasive mechanical ventilation | |
| Interventions | Aerosol administration using any type of device (nebulizer, metered-dose inhaled, dry powder inhaler, etc.) |
| Aerosol deposition assessment using pharmacokinetics or radioisotopic methods | |
| Outcomes | Pulmonary deposition of inhaled drug (dose, distribution or penetration) |
| Extrapulmonary deposition, if available | |
| Study designs | RCT, randomized comparative, crossover or cohort studies |