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Table 1 Inclusion criteria for studies according PICOS

From: Aerosol delivery during invasive mechanical ventilation: a systematic review

Participants Adult aged 18 years or older with invasive mechanical ventilation
or in vivo experimental model of adult invasive mechanical ventilation
Interventions Aerosol administration using any type of device (nebulizer, metered-dose inhaled, dry powder inhaler, etc.)
Aerosol deposition assessment using pharmacokinetics or radioisotopic methods
Outcomes Pulmonary deposition of inhaled drug (dose, distribution or penetration)
Extrapulmonary deposition, if available
Study designs RCT, randomized comparative, crossover or cohort studies
  1. PICOS participants, interventions, comparisons, outcomes and study design, RCT randomized controlled trial