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Abbreviations: CLCR
CG
Creatinine clearance estimated according to Cockcroft and Gault equation [34], CRRT Continuous renal replacement therapy, C
X
Concentration at specific time point X of concentration-time profile, I/R Intermediate/resistant, PK/PD Pharmacokinetic/pharmacodynamic, RF Renal function, RI Renal impairment, S/I Susceptible/intermediate
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1Patients were assigned to a renal function class on the basis of their median individual CLCRCG at the time of C4h or C8h determination