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Table 1 Characteristics of all patients according to neurological outcome 90 days after return of spontaneous circulation

From: Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein

  CPC 1 and 2
(n = 25)
CPC 3–5
(n = 103)
p Value
CPC 90 days after ROSC, n (%)
 1 24 (96) 0 (0)  
 2 1 (4) 0 (0)  
 3 0 (0) 13 (12.6)  
 4 0 (0) 17 (16.5)  
 5 0 (0) 73 (70.9)  
Background
 Cardiac etiology, n (%) 23 (92) 50 (49) 0.001
 Age, median (IQR) 60 (48–71) 72 (63–83) 0.001
 Male sex, n (%) 24 (96) 64 (62) 0.001
 Witness, n (%) 18 (72) 72 (70) 1.00
 Bystander CPR, n (%) 14 (56) 37 (36) 0.073
 Initial shockable wave, n (%) 17 (68) 30 (29) 0.001
 Time interval from emergency call to ROSC, minutes, mean ± SD 28.4 ± 22.3 46.7 ± 25.0 <0.001
 Adrenaline administration, mg, median (IQR) 0 (0–1) 2 (1–3) 0.001
 PCI performed, n (%) 13 (52) 21 (20) 0.002
 Therapeutic hypothermia performed, n (%) 17 (68) 53 (51) 0.18
 Required vasopressor, yes, n (%) 7 (28) 77 (75) <0.001
SOFA score
 SOFA on admission, mean ± SD 8.1 ± 2.6 10.1 ± 2.6 0.001
 SOFA excluding GCS, mean ± SD 4.2 ± 2.7 6.1 ± 2.5 0.001
  GCS 3.9 ± 0.3 4.0 ± 0.1 0.223
  PaO2/FiO2 ratio 2.4 ± 1.6 2.7 ± 1.4 0.448
  Circulation 1.0 ± 1.4 2.2 ± 1.4 <0.001
  Total bilirubin 0 ± 0.0 0.1 ± 0.3 0.011
  Creatinine 0.7 ± 1.1 0.7 ± 1.1 0.94
  Platelet 0.7 ± 0.3 0.5 ± 0.7 0.001
  1. Abbreviations: ROSC Return of spontaneous circulation, CPC Glasgow-Pittsburgh Cerebral Performance Categories Scale, CPR Cardiopulmonary resuscitation, PCI Percutaneous coronary Intervention, TH Therapeutic hypothermia, SOFA Sequential Organ Failure Assessment, PaO 2 /FiO 2 Ratio of partial pressure of arterial oxygen to fraction of inspired oxygen, GCS Glasgow Coma Scale
  2. Required vasopressor refers to patients who needed an intravenous vasopressor after initial resuscitation on the first hospital day. Parametric data are presented as mean ± SD. Nonparametric data are presented as median with IQR. Categorical data are presented as n (%). The percentages in parentheses are the ratios for poor outcome or good outcome. Statistical significance was set at p < 0.05