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Table 1 Characteristics of all patients according to neurological outcome 90 days after return of spontaneous circulation

From: Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein

 

CPC 1 and 2

(n = 25)

CPC 3–5

(n = 103)

p Value

CPC 90 days after ROSC, n (%)

 1

24 (96)

0 (0)

 

 2

1 (4)

0 (0)

 

 3

0 (0)

13 (12.6)

 

 4

0 (0)

17 (16.5)

 

 5

0 (0)

73 (70.9)

 

Background

 Cardiac etiology, n (%)

23 (92)

50 (49)

0.001

 Age, median (IQR)

60 (48–71)

72 (63–83)

0.001

 Male sex, n (%)

24 (96)

64 (62)

0.001

 Witness, n (%)

18 (72)

72 (70)

1.00

 Bystander CPR, n (%)

14 (56)

37 (36)

0.073

 Initial shockable wave, n (%)

17 (68)

30 (29)

0.001

 Time interval from emergency call to ROSC, minutes, mean ± SD

28.4 ± 22.3

46.7 ± 25.0

<0.001

 Adrenaline administration, mg, median (IQR)

0 (0–1)

2 (1–3)

0.001

 PCI performed, n (%)

13 (52)

21 (20)

0.002

 Therapeutic hypothermia performed, n (%)

17 (68)

53 (51)

0.18

 Required vasopressor, yes, n (%)

7 (28)

77 (75)

<0.001

SOFA score

 SOFA on admission, mean ± SD

8.1 ± 2.6

10.1 ± 2.6

0.001

 SOFA excluding GCS, mean ± SD

4.2 ± 2.7

6.1 ± 2.5

0.001

  GCS

3.9 ± 0.3

4.0 ± 0.1

0.223

  PaO2/FiO2 ratio

2.4 ± 1.6

2.7 ± 1.4

0.448

  Circulation

1.0 ± 1.4

2.2 ± 1.4

<0.001

  Total bilirubin

0 ± 0.0

0.1 ± 0.3

0.011

  Creatinine

0.7 ± 1.1

0.7 ± 1.1

0.94

  Platelet

0.7 ± 0.3

0.5 ± 0.7

0.001

  1. Abbreviations: ROSC Return of spontaneous circulation, CPC Glasgow-Pittsburgh Cerebral Performance Categories Scale, CPR Cardiopulmonary resuscitation, PCI Percutaneous coronary Intervention, TH Therapeutic hypothermia, SOFA Sequential Organ Failure Assessment, PaO 2 /FiO 2 Ratio of partial pressure of arterial oxygen to fraction of inspired oxygen, GCS Glasgow Coma Scale
  2. Required vasopressor refers to patients who needed an intravenous vasopressor after initial resuscitation on the first hospital day. Parametric data are presented as mean ± SD. Nonparametric data are presented as median with IQR. Categorical data are presented as n (%). The percentages in parentheses are the ratios for poor outcome or good outcome. Statistical significance was set at p < 0.05