Fig. 5

Box plot comparing biomarkers by outcome in cardiac etiology. The Mann-Whitney U test was performed. Analysis results are shown by box plot on a logarithmic scale. Serum level of high-mobility group box 1 protein (HMGB1) (a), neuron-specific enolase (NSE) (b) and interleukin (IL)-6 (c) were compared with group Glasgow-Pittsburgh Cerebral Performance Categories Scale (CPC) 3–5 and CPC 1 or 2 at 0, 24, 48, and 168 h (7 days) in cardiac etiology for subanalysis. Statistical significance was set at p < 0.05 (*) and p < 0.001 (**) above the box plot. The horizontal bold line in the middle of the box is the median value. The box is the IQR from the first quartile to the third quartile. Whiskers are the range of maximum and minimum values between 1.5 times IQR above the third quartile and 1.5 times IQR below the first quartile. Open circles are the outliers between 1.5 and 3 times IQR either above the third quartile or below the first quartile. Asterisks are the outliers three times the IQR either above the third quartile or below the first quartile. Numbers of patients in the graphs are 0 h (n = 23), 24 h (n = 23), 48 h (n = 23), 168 h (n = 23) for CPC 1 or 2; and 0 h (n = 50), 24 h (n = 45), 48 h (n = 39), 168 h (n = 27) for CPC 3 or 4