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Fig. 2 | Critical Care

Fig. 2

From: Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein

Fig. 2

Variability of biomarkers (high-mobility group box 1 protein [HMGB1], neuron-specific enolase [NSE], and interleukin [IL]-6) from return of spontaneous circulation (ROSC). Biomarker variability was analyzed from ROSC to 7 days using box plots for HMGB1 (a), NSE (b), and IL-6 (c). Measurement points were at 0, 24, 48, and 168 h (7 days) after ROSC. This plot is presented on a logarithmic scale. Statistical significance was set at p < 0.05 (*) and p < 0.001 (**) in the box plot. This box plot consists of boxes, whiskers, open circles, and asterisks using a logarithmic scale. The horizontal bold line in the middle of the box is the median value. The box is the IQR from the first quartile to the third quartile. Whiskers are the range of maximum and minimum values between 1.5 times IQR above the third quartile and 1.5 times IQR below the first quartile. Open circles are the outliers between 1.5 and 3 times IQR either above the third quartile or below the first quartile. Asterisks are the outliers three times the IQR either above the third quartile or below the first quartile. Number of patients in the graphs are 0 h (n = 128), 24 h (n = 114), 48 h (n = 101), and 168 h (n = 82)

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Critical Care

ISSN: 1364-8535