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Table 3 Studies on primary FMT in nonrecurring CDI

From: Sleeping with the enemy: Clostridium difficile infection in the intensive care unit

Study group Patients included ICU patients Cure rates Description
Agraval et al., 2015 [80] 146 total (57 with severe or complicated CDI) ? 82.9% primary 95.9% overall All patients 65 years and older Varying protocol for FMT
Aroniadis et al., 2015 [81] 17 with severe or complicated CDI ? 88.2% primary 94.1% overall  
Fisher et al., 2015 [82] 29 13 62% primary 93% overall Treatment protocol with FMT (colonoscopy) and continued vancomycin
 Pecere et al., 2015 [83] 1    Altered protocol with FMT and fidaxomicin
Zainah et al., 2014 [84] 14 with severe CDI 6 79% FMT via NGT
Lagier et al., 2015 [59] 61 patients with CDI (O27) ? 81.25% (vs 35.6%) 42 patients treated with antibiotics 3 patients treated with “tardive” FMT 16 patients treated with antibiotics and early FMT
Kelly et al., 2014 [85] 80 total (34% severe CDI) ? 78% primary 89% overall Study on immunocompromised patients; disease flares in 14% of patients with inflammatory bowel disease
Gweon et al., 2016 [86] 7 total (2 with severe CDI) ? 100% overall Study on older, multimorbid patients with primary FMT (administered orally)
  1. CDI Clostridium difficile infection, NGT nasogastric tube, FMT fecal matter transplantation