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Table 3 Studies on primary FMT in nonrecurring CDI

From: Sleeping with the enemy: Clostridium difficile infection in the intensive care unit

Study group Patients included ICU patients Cure rates Description
Agraval et al., 2015 [80] 146 total
(57 with severe or complicated CDI)
? 82.9% primary
95.9% overall
All patients 65 years and older
Varying protocol for FMT
Aroniadis et al., 2015 [81] 17 with severe or complicated CDI ? 88.2% primary
94.1% overall
 
Fisher et al., 2015 [82] 29 13 62% primary
93% overall
Treatment protocol with FMT (colonoscopy) and continued vancomycin
 Pecere et al., 2015 [83] 1    Altered protocol with FMT and fidaxomicin
Zainah et al., 2014 [84] 14 with severe CDI 6 79% FMT via NGT
Lagier et al., 2015 [59] 61 patients with CDI (O27) ? 81.25%
(vs 35.6%)
42 patients treated with antibiotics
3 patients treated with “tardive” FMT
16 patients treated with antibiotics and early FMT
Kelly et al., 2014 [85] 80 total
(34% severe CDI)
? 78% primary
89% overall
Study on immunocompromised patients; disease flares in 14% of patients with inflammatory bowel disease
Gweon et al., 2016 [86] 7 total
(2 with severe CDI)
? 100% overall Study on older, multimorbid patients with primary FMT (administered orally)
  1. CDI Clostridium difficile infection, NGT nasogastric tube, FMT fecal matter transplantation