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Table 2 Synoptic overview of suggested markers to predict disease severity in CDI

From: Sleeping with the enemy: Clostridium difficile infection in the intensive care unit

Prediction markers
 Declining renal function [14]
 Treatment with systemic antibiotics [13]
 Age [12,13,14, 79]
 White blood cell count [13, 79]
 Albumin [79]
 Steroid therapy [79]
 Admission due to diarrhea [12]
 Recent abdominal surgery [12]
 Hypotension [12]
 Diagnosis of CDI in the ICU [12]
 Readmission with recurring infection
 Transfer to ICU because of CDI
 Emergency surgery
 Ribotype O27
 Lactoferrin, fecal calprotectin
No predictive value
 Fever [79]
 Hemoglobin [79]
 Intensity [79]
 Comorbidity (diabetes, cancer) [79]
  1. CDI Clostridium difficile infection, ICU intensive care unit