From: Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin
 | All (n = 514) | Non-AKI (n = 163) | AKI (n = 351) | P value |
---|---|---|---|---|
Laboratory tests | ||||
 WBC, 109/L | 9.9 (4.2–15.0) | 9.5 (5.0–14.2) | 10.1 (3.7–15.2) | 0.255 |
 Hb, g/L | 105 (89–121) | 107 (93–122) | 104 (86–120) | 0.023 |
 CRP, mg/L | 128 (62–225) | 105 (41–186) | 137 (70–242) | 0.002 |
 Alb, g/L | 24 (20–28) | 24 (21–28) | 23 (19–28) | 0.013 |
 T-Bil, μmol/L | 15.2 (10.8–24.8) | 15.6 (11.1–23.8) | 15.0 (10.6–25.8) | 0.395 |
 Lactate, mmol/L | 2.2 (1.4–3.7) | 1.9 (1.2–2.7) | 2.5 (1.5–4.6) | <0.0001 |
 BNP, ng/L | 136.7 (50.6–395.1) | 70.2 (29.8–204.8) | 175.0 (68.1–522.7) | 0.0003 |
Renal parameters | ||||
 BUN, mmol/L | 8.9 (5.4–14.6) | 5.4 (3.9–7.9) | 11.4 (7.5–16.6) | <0.0001 |
 Creatinine, μmol/L | 89.7 (61.0–162.9) | 57.5 (47.7–69.0) | 127.3 (84.9–206.9) | <0.0001 |
 Creatinine, mg/dl | 1.02 (0.69–1.84) | 0.65 (0.54–0.78) | 1.44 (0.96–2.34) | <0.0001 |
 Cystatin C, mg/L | 1.29 (0.91–2.02) | 0.86 (0.72–1.03) | 1.65 (1.14–2.29) | <0.0001 |
Coagulation biomarkers | ||||
 Platelets, 109/L | 144 (91–207) | 167 (127–238) | 131 (78–193) | <0.0001 |
 FDP, mg/L | 16.7 (10.0–27.6) | 13.6 (8.9–21.7) | 18.9 (10.9–30.5) | 0.049 |
 PT, % | 56.4 (44.3–70.3) | 63.3 (50.3–75.8) | 52.4 (42.5–67.6) | <0.0001 |
 Fib, mg/dl | 343 (242–487) | 373 (261–528) | 333 (234–471) | 0.076 |
 α2-PI, % | 75.2 (57.9–97.2) | 82.0 (63.3–102.0) | 73.6 (56.9–94.0) | 0.029 |
 AT III, % | 53.7 (41.9–69.0) | 60.4 (45.5–76.3) | 51.5 (39.3–63.0) | <0.0001 |
 Plasminogen, % | 61.4 (46.2–80.3) | 66.9 (52.9–88.8) | 59.7 (43.6–77.6) | 0.0002 |
 TAT, ng/ml | 11.1 (6.2–20.0) | 9.2 (5.4–16.7) | 12.4 (6.7–21.5) | 0.088 |
 PIC, μg/ml | 1.3 (0.8–2.1) | 1.2 (0.8–1.9) | 1.3 (0.8–2.2) | 0.613 |
Endothelial activation | ||||
 Protein C, % | 49.6 (36.3–66.4) | 58.7 (44.2–74.0) | 45.9 (33.6–63.6) | <0.0001 |
 sTM, U/ml | 21.1 (15.4–31.5) | 15.6 (12.6–20.5) | 23.6 (17.0–38.8) | <0.0001 |
 E-selectin, ng/ml | 55.2 (36.2–98.2) | 46.2 (32.3–67.5) | 65.5 (40.2–131.0) | 0.0497 |
 PAI-1, ng/ml | 116.3 (53.8–290.8) | 75.3 (40.3–150.7) | 180.4 (68.0–519.1) | 0.018 |
Other definitions | ||||
 No renal SOFA | 6 (4–9) | 5 (3–7) | 7 (5–9) | <0.0001 |
 Overt DIC | 24.5% | 10.1% | 31.6% | <0.0001 |
 Septic shock | 45.7% | 29.5% | 53.3% | <0.0001 |