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Table 1 Characteristics of the study population

From: Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin

 

All (n = 514)

AKI (n = 163)

Non-AKI (n = 351)

P value

Age, years

69 (59–78)

65 (56–74)

71 (61–79)

0.0003

BW, kg

56.7 (48–66)

55 (46–64)

57 (49–67)

0.336

Height, cm

159 (151–166)

159 (152–166)

160 (150–166)

0.823

Male sex

53.9%

53.4%

54.1%

0.873

APACHE II

24 (18–30)

19 (15–25)

26 (20–31)

<0.0001

CKD

28.0%

21.5%

31.1%

0.032

Premorbid creatinine, μmol/L

66.3 (53.0–84.9)

61.9 (47.7–80.0)

70.3 (53.9–89.5)

0.007

 Premorbid creatinine, mg/dl

0.75 (0.60–0.96)

0.70 (0.54–0.91)

0.80 (0.0.61–1.01)

0.007

Baseline creatinine, μmol/L

54.8 (50.9–71.6)

55.1 (51.3–65.4)

54.8 (50.8–72.5)

0.011

 Baseline creatinine, mg/dl

0.62 (0.58–0.81)

0.62 (0.58–0.74)

0.62 (0.57–0.82)

0.011

Hypertension

48.8%

39.3%

53.3%

0.003

IHD

8.8%

5.5%

10.3%

0.077

CHF

8.8%

4.9%

10.5%

0.036

COPD

5.1%

7.4%

4.0%

0.104

CVA

11.1%

8.6%

12.3%

0.219

DM

25.7%

21.5%

27.6%

0.137

Immunocompromised

29.2%

27.6%

29.9%

0.592

Infection site

   

0.013

 Intracranial

1.2%

2.5%

0.6%

 

 Head and neck

5.5%

9.2%

3.7%

 

 Thoracic

22.4%

22.1%

22.5%

 

 Abdominal

50.8%

53.4%

49.6%

 

 Soft tissue

6.0%

4.9%

6.6%

 

 CR-BSI

1.0%

0.0%

1.4%

 

 UTI

5.3%

3.7%

6.0%

 

 Others

8.0%

4.3%

10.3%

 

Mechanical ventilation

82.9%

76.7%

85.8%

0.011

28-day mortality

11.7%

3.1%

15.6%

<0.0001

90-day mortality

19.3%

8.4%

24.5%

<0.0001

  1. Abbreviations: AKI Acute kidney injury, APACHE II Acute Physiology and Chronic Health Evaluation II score, BMI Body mass index, BW Body weight, CHD Chronic heart disease, CKD Chronic kidney disease, COPD Chronic obstructive pulmonary disease, CR-BSI Catheter-related bloodstream infection, CVA Cerebrovascular accident, DM Diabetes mellitus, IHD Ischemic heart disease, UTI Urinary tract infection