| TBI | P value | Non-TBI | P value | ||
---|---|---|---|---|---|---|
Hyperfibrinolysis (-) n = 77 | Hyperfibrinolysis (+) n = 34 | Hyperfibrinolysis (-) n = 80 | Hyperfibrinolysis (+) n = 46 | |||
Age, years | 61 (41–72) | 70 (51–83) | 0.028 | 45 (36–62) | 43 (26–70) | 0.895 |
Male, n (%) | 60 (78) | 23 (68) | 0.251 | 61 (76) | 25 (54) | 0.001 |
ISS | 17 (16–26) | 25 (25–26) | 0.011 | 20 (17–25) | 27 (18–34) | 0.003 |
Revised trauma score | 7.10 (6.17–7.84) | 5.50 (4.09–7.84) | <0.001 | 7.84 (7.55–7.84) | 7.55 (6.61–7.84) | 0.022 |
Heart rate, per min | 85 (75–93) | 84 (65–93) | 0.467 | 85 (71–98) | 96 (85–111) | 0.001 |
Systolic BP, mmHg | 144 (126–169) | 170 (138–193) | 0.004 | 122 (103–140) | 104 (87–128) | 0.016 |
Respiratory rate, per min | 19 (18–23) | 20 (16–25) | 0.774 | 22 (18–25) | 24 (20–30) | 0.036 |
Body temperature, °C | 36.2 (35.8–36.7) | 36.2 (35.6–36.8) | 0.708 | 36.5 (35.8–36.9) | 36.3 (35.7–36.6) | 0.210 |
Glasgow coma scale score | 13 (9–14) | 6 (3–13) | <0.001 | 14 (14–15) | 14 (12–15) | 0.017 |
Time from the accident to sample collection | ||||||
 0–30 min, n (%) | 21 (28) | 12 (35) | 0.469 | 17 (22) | 12 (27) | 0.641 |
 31–60 min, n (%) | 38 (51) | 18 (53) | 43 (54) | 21 (48) | ||
 61–90 min, n (%) | 5 (7) | 2 (6) | 13 (17) | 5 (11) | ||
 91–120 min, n (%) | 7 (9) | 0 (0) | 1 (1) | 1 (2) | ||
 Over 120 min, n (%) | 4 (5) | 2 (6) | 5 (6) | 5 (11) | ||
 Unknown, n (%) | 2 (3) | 0 (0) | 1 (1) | 2 (4) | ||
Arterial blood gas analyses | ||||||
 pH | 7.39 (7.35–7.43) | 7.39 (7.37–7.42) | 0.824 | 7.38 (7.34–7.43) | 7.36 (7.30–7.40) | 0.922 |
 Base deficit, mmol/L | 1.1 (-0.4–2.9) | 1.3 (-0.2–3.4) | 0.707 | 1.7 (0.1–3.9) | 2.4 (0.6–5.9) | 0.676 |
 Lactate, mmol/L | 2.40 (1.40–3.20) | 2.44 (1.70–2.89) | 0.738 | 2.30 (1.50–3.26) | 2.90 (2.00–5.77) | 0.454 |
Laboratory parameters | ||||||
 White blood cells, × 109/L | 8.7 (6.9–12.3) | 11.2 (8.9–13.5) | 0.013 | 11.1 (8.9–14.5) | 13.7 (10.2–17.9) | 0.009 |
 Haemoglobin, g/dL | 14.0 (12.8–14.9) | 13.1 (11.8–14.3) | 0.075 | 13.9 (12.0–14.8) | 12.2 (10.9–13.1) | <0.001 |
 Platelet count, × 109/L | 19.1 (15.6–24.1) | 17.0 (14.6–21.2) | 0.170 | 23.2 (18.7–26.6) | 20.2 (17.0–26.0) | 0.079 |
 AST, U/L | 29 (24–37) | 40 (29-49) | 0.022 | 63 (33–143) | 109 (64–196) | 0.004 |
 ALT, U/L | 24 (17–34) | 27 (17–34) | 0.813 | 44 (24–81) | 73 (40–116) | 0.011 |
 LDH, U/L | 249 (208–301) | 312 (262–377) | 0.001 | 378 (275–518) | 677 (523–1064) | <0.001 |
 CK, U/L | 144 (95–232) | 175 (115–300) | 0.183 | 289 (183–442) | 455 (258–749) | 0.001 |
 PT-INR | 1.00 (0.96–1.05) | 1.10 (0.97–1.17) | 0.005 | 1.02 (0.96–1.07) | 1.12 (1.06–1.20) | <0.001 |
 APTT, sec | 24.1 (22.5–26.2) | 29.8 (25.9-34.1) | <0.001 | 24.9 (23.1–27.1) | 28.1 (24.8–31.9) | <0.001 |
 Fibrinogen, mg/dL | 260 (219–299) | 207 (149–269) | 0.004 | 248 (206–293) | 215 (177–264) | 0.014 |
 D-dimer, μg/mL | 10.5 (5.8–23.5) | 93.2 (52.6–129.3) | <0.001 | 12.2 (5.8–23.0) | 65.0 (54.6–100.0) | <0.001 |