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Table 1 Characteristics of the patients

From: Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study

 

TBI

n = 111

Non-TBI

n = 126

P value

Age, years

64 (43–76)

44 (30–64)

<0.001

Male, n (%)

83 (75)

82 (65)

0.105

ISS

25 (17–26)

21 (17–27)

0.044

Revised trauma score

6.90 (5.97–7.84)

7.84 (7.11–7.84)

<0.001

Heart rate, per min

85 (74–93)

89 (76–103)

0.034

Systolic BP, mmHg

152 (129–178)

116 (96–138)

<0.001

Respiratory rate, per min

19 (18–24)

23 (18–28)

0.001

Body temperature, °C

36.2 (35.8–36.7)

36.4 (35.8–36.8)

0.334

Glasgow coma scale score

12 (6–14)

14 (13–15)

<0.001

Time from the accident to sample collection

 0–30 min, n (%)

33 (30)

29 (24)

0.122

 31–60 min, n (%)

56 (51)

64 (52)

 61–90 min, n (%)

7 (6)

18 (15)

 91–120 min, n (%)

7 (6)

2 (2)

 Over 120 min, n (%)

6 (6)

10 (8)

 Unknown, n (%)

2 (2)

3 (2)

Arterial blood gas analyses

 pH

7.39 (7.35–7.42)

7.38 (7.33–7.42)

0.061

 Base deficit, mmol/L

1.2 (-0.4–3.0)

1.8 (0.2–4.4)

0.044

 Lactate, mmol/L

2.40 (1.40–3.20)

2.65 (1.70–3.62)

0.081

Laboratory parameters

 White blood cells, × 109/L

9.9 (7.3–12.8)

11.8 (9.2–16.0)

<0.001

 Haemoglobin, g/dL

13.7 (12.4–14.8)

12.8 (11.3–14.4)

0.009

 Platelet count, × 109/L

18.3 (14.7–23.5)

22.9 (18.2–26.3)

<0.001

 AST, U/L

31 (25–44)

76 (45–156)

<0.001

 ALT, U/L

25 (17–34)

49 (29–100)

<0.001

 LDH, U/L

270 (217–327)

469 (348–723)

<0.001

 CK, U/L

149 (99–246)

317 (214–532)

<0.001

 PT-INR

1.01 (0.96–1.10)

1.06 (0.99–1.13)

0.009

 APTT, sec

25.0 (23.0–28.2)

25.6 (23.5–29.0)

0.306

 Fibrinogen, mg/dL

246 (181–296)

229 (196–280)

0.569

 D-dimer, μg/mL

22.4 (7.6–49.6)

23.8 (8.1–58.6)

0.500

  1. ISS injury severity score, BP blood pressure, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH lactate dehydrogenase, CK creatine kinase, PT-INR prothrombin time–international normalized ratio, APTT activated partial thromboplastin time