Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment

Table 2 Demographic and clinical characteristics associated with more severe SAB

Characteristic	Impact
Community-acquired infection	Tends to metastasize
Female gender	Increased risk of mortality vs males
Positive blood cultures present for longer than 48 h	Complicated course (including metastatic infections)
Persistent fever at 72 h	Complicated course
Time for blood culture to turn positive	Complicated course (including metastatic infections and increased risk of mortality)
Lack of identifiable focus	Aggravates and prolongs SAB
Skin lesions suggestive of acute systemic infection	Complicated course
Implanted prosthetic device	Complicated course (including increased risk of mortality and relapse)
Immunosuppression and HIV	Aggravates and prolongs SAB
Renal failure	Intravascular complications
Solid tumors	Intravascular complications
APACHE II score >7	Complicated course (including increased risk of septic shock and mortality)
CURB-65 score >3	Complicated course (including increased risk of septic shock and mortality)
Neurologic complications	Increased risk of mortality
Cardiac complications	Increased risk of mortality
Septic thrombophlebitis	Prolonged clinical course
MRSA pneumonia	Complicated course (including increased risk of septic shock and mortality)

Portions of this table were reproduced with permission from Table 1 in Keynan and Rubinstein [7] and additional information was adapted from Corey [58]
Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, CURB-65 confusion, urea, respiratory rate, blood pressure, and age 65, HIV human immunodeficiency virus, MRSA methicillin-resistant S. aureus, SAB S. aureus bacteremia

ISSN: 1364-8535