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Table 2 Demographic and clinical characteristics associated with more severe SAB

From: Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment

Characteristic Impact
Community-acquired infection Tends to metastasize
Female gender Increased risk of mortality vs males
Positive blood cultures present for longer than 48 h Complicated course (including metastatic infections)
Persistent fever at 72 h Complicated course
Time for blood culture to turn positive Complicated course (including metastatic infections and increased risk of mortality)
Lack of identifiable focus Aggravates and prolongs SAB
Skin lesions suggestive of acute systemic infection Complicated course
Implanted prosthetic device Complicated course (including increased risk of mortality and relapse)
Immunosuppression and HIV Aggravates and prolongs SAB
Renal failure Intravascular complications
Solid tumors Intravascular complications
APACHE II score >7 Complicated course (including increased risk of septic shock and mortality)
CURB-65 score >3 Complicated course (including increased risk of septic shock and mortality)
Neurologic complications Increased risk of mortality
Cardiac complications Increased risk of mortality
Septic thrombophlebitis Prolonged clinical course
MRSA pneumonia Complicated course (including increased risk of septic shock and mortality)
  1. Portions of this table were reproduced with permission from Table 1 in Keynan and Rubinstein [7] and additional information was adapted from Corey [58]
  2. Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, CURB-65 confusion, urea, respiratory rate, blood pressure, and age 65, HIV human immunodeficiency virus, MRSA methicillin-resistant S. aureus, SAB S. aureus bacteremia