Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial

Table 2 Respiratory parameters at screening

Parameter	AP301 (n = 20)	Placebo (n = 20)
PaO₂/FiO₂, mmHg	147 ± 48	150 ± 59
Murray LIS	2.9 ± 0.5	2.8 ± 0.5
Oxygenation index	12.8 ± 5.5	10.6 ± 5.0
Prone positioning	6 (30)	5 (25)
ECMO therapy	4 (20)	1 (5)
EVLWI, mL/kg PBW	13.6 ± 5.6	12.5 ± 5.0
Peak ventilator pressure, cmH₂O	26 ± 4	25 ± 4
Driving pressure, cmH₂O	14 ± 3	14 ± 4
Mean airway pressure, cmH₂O	17 ± 4	15 ± 3
PEEP, cmH₂O	12 ± 3	11 ± 2
V_T, mL/kg PBW	6.7 ± 1.7	7.8 ± 1.6
Respiratory rate, per min	18 ± 6	18 ± 3
PaCO₂, mmHg	46 ± 7	44 ± 9
pH	7.37 ± 0.10	7.40 ± 0.07

Data are presented as mean ± SD or n (%)
ECMO extracorporeal membrane oxygenation, EVLWI extravascular lung water index, LIS lung injury score, PBW predicted body weight, PEEP positive end expiratory pressure, V _T tidal volume

ISSN: 1364-8535