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Table 2 Top 20 associated metabolites by logistic regression analysis

From: Metabolome alterations in severe critical illness and vitamin D status

Metabolite

Odds ratio adjusted vitamin D sufficiencya

P

Odds ratio adjusted 28-day mortalityb

P value

Class

1,5-Anhydroglucitol

2.92

0.001

0.97

0.85

Carbohydrate

Methylglutaroylcarnitine

0.31

0.002

1.07

0.70

Amino acid

Glucuronate

0.52

0.005

1.54

0.018

Carbohydrate

2-Hydroxyisobutyrate

0.52

0.011

1.32

0.20

Amino acid

1-Palmitoylglycerophosphoinositol

2.36

0.018

1.95

0.028

Lipid

4-Methyl-2-oxopentanoate

2.77

0.019

1.20

0.63

Amino acid

C-glycosyltryptophan

0.34

0.020

1.57

0.14

Amino acid

Bilirubin (E,E) isomer

2.18

0.021

2.36

0.005

Cofactors

Pyroglutamine

1.99

0.023

2.51

0.004

Amino acid

Tryptophan betaine

1.60

0.026

1.03

0.86

Amino acid

4-Acetamidobutanoate

0.50

0.027

1.36

0.20

Amino acid

3-Hydroxyoctanoate

2.46

0.030

1.55

0.17

Lipid

Prolylhydroxyproline

0.53

0.036

1.27

0.30

Peptide

Pseudouridine

0.38

0.038

1.55

0.17

Nucleotide

N-acetylalanine

0.23

0.045

2.53

0.081

Amino acid

2-Hydroxybutyrate

1.90

0.046

1.84

0.044

Amino acid

Biliverdin

1.72

0.048

2.34

0.003

Cofactors

N-acetylneuraminate

0.49

0.048

1.38

0.24

Carbohydrate

Tryptophan

2.39

0.049

2.83

0.031

Amino acid

4-Androsten-3beta,17beta-diol disulfate 1

0.66

0.050

1.09

0.57

Lipid

  1. Metabolite levels were log-transformed for analysis. The seven metabolites significantly associated with vitamin D status and 28-day mortality are shown in italic text under “Metabolite”. Odds ratios <1.00 indicate association between a metabolite and 25(OH)D ≤ 15 ng/ml. The significance threshold was set at p < 0.05
  2. aOdds ratios and p values are for association with plasma vitamin D sufficiency (25(OH)D > 15 ng/ml), after adjustment for age, gender, race, sepsis, glomerular filtration rate and malignancy status
  3. bOdds ratios and p values are for association with 28-day mortality after adjustment for Acute Physiology and Chronic Health Evaluation II