Skip to main content
Fig. 4 | Critical Care

Fig. 4

From: Metabolome alterations in severe critical illness and vitamin D status

Fig. 4

Network of metabolite-protein interactions inferred by metabolomics analysis. The names of the seven metabolites associated with vitamin D status and 28-day mortality (listed in Table 2), in addition to “vitamin D”, were used as input to generate a network of protein-protein and metabolite-protein interactions using the Search Tool for Interactions of Chemicals (STITCH) database. Network nodes are represented as either cylinders (chemicals) or circles (proteins, i.e. predicted functional partners), where nodes are colored if they are directly linked to the input, or white if they are of a higher iteration/depth (i.e. inferred by the network). Lines between nodes (edges) indicate predicted functional links, where stronger associations are represented by thicker lines; protein-protein interactions are shown in blue, chemical-protein interactions are shown in green, and interactions between chemicals are shown in red. Links between chemicals are not used to extend the network

Back to article page