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Table 2 Predicted marginal mean values and 95% CIs for haemostatic parameters, by experimental group and overall Wald P values derived from mixed effects regression models

From: Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support

  Ventilation only S-ALI control ECMO control S-ALI + ECMO Wald P value
WCC 8.4 (6.8–9.9) 5.5 (4.4–6.7) 6.0 (4.8–7.2) 4.9 (3.8–6) 0.004
RCC 6.9 (6.3–7.5) 7.3 (6.9–7.8) 5.0 (4.5–5.5) 6.2 (5.7–6.6) <0.001
Hb 75 (70–81) 87 (83–91) 55 (50–60) 73 (69–77) <0.001
PLT 195 (121–269) 248 (188–309) 238 (185–290) 207 (155–260) 0.609
PT 16 (13.4–18.6) 20 (17.7–22.2) 18.9 (16.7–21) 23.7 (22.1–25.3) 0.007
aPTT 113 (89–137) 117 (96–139) 100 (80–119) 124 (106–141) 0.164
TCT 68 (36–99) 96 (69–122) 159 (133–184) 104 (82–127) 0.063
d-dimer 211 (98–324) 157 (71–242) 332 (232–432) 276 (195–358) 0.852
Fib(C) 2.7 (2.4–3) 2.0 (1.7–2.3) 2.2 (1.9–2.4) 1.4 (1.2–1.6) <0.001
FVIII 1161 (1016–1307) 1082 (956–1208) 529 (410–647) 505 (415–595) <0.001
FXII 70 (59–81) 22 (13–31) 63 (55–72) 13 (6–20) <0.001
vWAg 135 (120–151) 130 (118–142) 92 (79–106) 103 (92–114) <0.001
Protein C 23 (17–29) 15 (10–20) 51 (47–56) 14 (9–18) <0.001
INTEM-CFT 323 (154–492) 332 (179–486) 211 (115–306) 235 (121–348) 0.468
INTEM-MCF 67 (55–79) 52 (41–63) 64 (57–71) 58 (52–64) <0.001
HEPTEM-CFT 92 (35–149) 89 (46–132) 136 (85–187) 105 (65–146) 0.5416
HEPTEM-MCF 69 (65–74) 67 (63–71) 70 (65–74) 60 (57–63) 0.001
EXTEM-CFT 108 (87–130) 144 (127–160) 105 (90–121) 179 (164–194) <0.001
EXTEM-MCF 75 (71–78) 71 (68–74) 71 (68–74) 63 (61–65) <0.001
FIBTEM-MCF 29 (26–33) 23 (20–26) 23 (20–26) 16 (14–19) <0.001
  1. Abbreviations: aPTT Activated partial thromboplastin time, AT Anti-thrombin, CFT Clot formation time, ECMO Extracorporeal membrane oxygenation, Fib(C) Clauss fibrinogen, FVIII Factor VIII, FXII Factor XII, Hb Haemoglobin, MCF Maximum clot firmness, PLT Platelets, PT Prothrombin time, RCC Red cell count, S-ALI Smoke-induced acute lung injury, TCT Thrombin clotting time, vWAg von Willebrand factor antigen, WCC White cell count
  2. Data are presented as predicted mean (95% CI)